The influence of chitosan, cellulose and alginate chemical nature on mineral matrix formation

Author(s)

Montrezor, Luis Henrique ; Dercore Benevenuto, Luiz Guilherme ; Antunes, Bruna Fernandes ; Amaral, Andre Capaldo ; Novo, Lisias Pereira ; Felix Carvalho, Antonio Jose ; Trovatti, Eliane

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS; v. 71, n. 12, p. 11-pg., 2021-05-12.

Abstract

Cell carriers such as chitosan, alginate and cellulose play a crucial role in cell behavior, however the influence of their chemical nature on osteogenesis is little studied. Here, rat bone marrow cells were grown on the surface of those polymers. The cells remained viable and produced a mineral matrix, which was deposited on the surface of all the polymers. The amount of inorganic matrix significantly varied according to the polymer, and the morphology of the inorganic matrix was influenced by the nature of the substrates, generating perfect hexagonal crystals at the surface of chitosan, alginate and cellulose. (AU)

• FAPESP's process: 18/14840-4 - Bacterial cellulose membrane superficially modified by plasma for tissue engineering application
• Grantee: Luíz Guilherme Dércore Benevenuto
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 16/02811-4 - Laser therapy and cell therapy in rats induced to ovarian syndrome polycystic
• Grantee: Luis Henrique Montrezor
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/18782-6 - Click chemistry platform for the development of polymer-based materials for regenerative medicine
• Grantee: Eliane Trovatti
• Support Opportunities: Research Grants - Young Investigators Grants