| Full text | |
| Author(s): Show less - |
Silveira, Heitor Albergoni
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Almeid, Luciana Yamamoto
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Carlos, Roman
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Silvaa, Evanio Vilela
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Ferrisse, Tulio Morandin
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Duarte, Andressa
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Cardoso, Suziene Caroline Sivailva
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Polanco, Xiomara Beatriz Jimenez
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Bufalino, Andreia
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Ribeiro-Silva, Alfredo
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Leon, Jorge Esquihe
Total Authors: 11
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| Document type: | Journal article |
| Source: | AURIS NASUS LARYNX; v. 49, n. 2, p. 13-pg., 2022-03-12. |
| Abstract | |
Objectives: While unknown for oropharyngeal squamous cell carcinoma (OPSCC) and oral squamous cell carcinoma (OSCC), some studies assessing cervical carcinoma have shown that human papillomavirus (HPV) co-infection can be associated with its prognosis.& nbsp;Methods: Through in situ hybridization (HPV and Epstein-Barr virus [EBV] probes) and immunohistochemistry (p16(INK4a), cyclin D1, p53, and Ki-67 antibodies), 126 OPSCC and 109 OSCC samples were assessed.& nbsp;Results: All patients were EBV-negative. OPSCC (25%) showed a significant association with HPV compared to OSCC (11%). Almost all HPV-associated cases were p16(INK4a)-positive. Regarding OPSCC and OSCC, 23 and 7 cases were positive for high-risk HPV (HRHPV) only, 6 and 3 cases for low-risk HPV (LRHPV) only, and 3 and 2 cases for HRHPV/LRHPV, respectively. HPV-associated carcinomas showed a significantly higher proliferative index than HPV-unassociated carcinomas. Both carcinomas showed a similar overall survival rate, which was not affected by the HPV status. However, when comparing HPV-associated subgroups, patients with HRHPV/LRHPV-associated carcinomas showed worse survival.& nbsp;Conclusion: LRHPV-associated and HRHPV/LRHPV-associated cases can also be detected when assessing OSCC and OPSCC. Further studies, especially in populations with a high prevalence of HPV-associated OPSCC, are necessary to understand the clinicopathological behavior of these neoplasm subgroups. (C)& nbsp;2021 Japanese Society of Otorhinolaryngology-Head and Neck Surgery, Inc. Published by Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: in vitro, ex vivo and murine experimental model studies. |
| Grantee: | Luciana Yamamoto de Almeida |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region. |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma |
| Grantee: | Heitor Albergoni da Silveira |
| Support Opportunities: | Scholarships in Brazil - Master |