| Full text | |
| Author(s): |
de Freitas Pedrosa, Lucas
;
Fabi, Joao Paulo
Total Authors: 2
|
| Document type: | Journal article |
| Source: | CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION; v. N/A, p. 21-pg., 2023-01-02. |
| Abstract | |
Colorectal cancer is the third most incident and second most lethal type of cancer worldwide. Lifestyle and dietary patterns are the key factors for higher disease development risk. The dietary fiber intake from fruits and vegetables, mainly formed by food hydrocolloids, can help to lower the incidence of this type of neoplasia. Different food polysaccharides have applications in anti-tumoral therapy, such as coadjuvant to mainstream drugs, carriage-like properties, or direct influence on tumoral cells. Some classes include inulin, beta-glucans, pectins, fucoidans, alginates, mucilages, and gums. Therefore, it is fundamental to discuss colorectal cancer mechanisms and the roles played by different polysaccharides in intestinal health. Genetic, environmental, and immunological modulation of mutated pathways regarding colorectal cancer has been explored before. Microbial diversity, byproduct formation (primarily short-chain fatty acids), inflammatory profile control, and tumoral mutated pathways regulation are thoroughly explored mechanisms by which dietary fiber sources influence a healthy gut ambiance. (AU) | |
| FAPESP's process: | 19/11816-8 - Effect of papaya modified fibers on three-dimensional co-culture of human colon cancer cells and on in vivo model of rats with chemically induced colon carcinogenesis |
| Grantee: | Joao Paulo Fabi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/07914-8 - FoRC - Food Research Center |
| Grantee: | Bernadette Dora Gombossy de Melo Franco |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 20/08063-5 - Study of the biological effects of modified passion fruit pectins using in vitro and in vivo models of Colon Carcinogenesis |
| Grantee: | Lucas de Freitas Pedrosa |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |