The complement system as a key modulator of the oral microbiome in health and disease

Author(s)

Mattos-Graner, Renata O. ; Klein, Marlise I. ; Alves, Livia Araujo

• Document type: Journal article
• Source: CRITICAL REVIEWS IN MICROBIOLOGY; v. N/A, p. 30-pg., 2023-01-05.

Abstract

In this review, we address the interplay between the complement system and host microbiomes in health and disease, focussing on oral bacteria known to contribute to homeostasis or to promote dysbiosis associated with dental caries and periodontal diseases. Host proteins modulating complement activities in the oral environment and expression profiles of complement proteins in oral tissues were described. In addition, we highlight a sub-set of bacterial proteins involved in complement evasion and/or dysregulation previously characterized in pathogenic species (or strains), but further conserved among prototypical commensal species of the oral microbiome. Potential roles of these proteins in host-microbiome homeostasis and in the emergence of commensal strain lineages with increased virulence were also addressed. Finally, we provide examples of how commensal bacteria might exploit the complement system in competitive or cooperative interactions within the complex microbial communities of oral biofilms. These issues highlight the need for studies investigating the effects of the complement system on bacterial behaviour and competitiveness during their complex interactions within oral and extra-oral host sites. (AU)

• FAPESP's process: 12/04222-5 - Analysis of the roles of the transcriptional regulators VicRK and CovR in the susceptibility of Streptococcus mutans to opsonization by the complement system.
• Grantee: Lívia Araújo Alves
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 21/13074-9 - Identification of genes of Streptococcus sanguinis involved in its capacity to invade, persist and functionally affect human endothelial cells
• Grantee: Renata de Oliveira Mattos Graner
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/12940-3 - Identification of surface proteins of Streptococcus mutans involved in evasion of opsonization by the complement system
• Grantee: Renata de Oliveira Mattos Graner
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/17216-4 - Analysis of the functions of pepO protein in systemic virulence of Streptococcus mutans
• Grantee: Lívia Araújo Alves
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 12/50966-6 - Analysis of the roles of the transchptional regulators VicRK and CovR in the susceptibility of Streptococcus mutans and Streptococcus sanguinis to opsonization by the complement system
• Grantee: Renata de Oliveira Mattos Graner
• Support Opportunities: Regular Research Grants
• FAPESP's process: 12/51832-3 - Analysis of a new Two Component System possibly involved in the adaptation of Streptococcus mutans and Streptococcus sanguinis to human saliva.
• Grantee: Renata de Oliveira Mattos Graner
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/19899-4 - Identification of factors modulating the susceptibility of Streptococcus sanguinis to complement immunity
• Grantee: Lívia Araújo Alves
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/06801-1 - Extracellular matrix: from biology to strategies for controlling cariogenic biofilms
• Grantee: Marlise Inêz Klein Furlan
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 18/02054-4 - Identification of factors modulating the susceptibility of Streptococcus sanguinis to complement immunity
• Grantee: Renata de Oliveira Mattos Graner
• Support Opportunities: Regular Research Grants
• FAPESP's process: 15/07237-1 - Identification of surface proteins of Streptococcus mutans involved in the scape to opsonization by the complement system
• Grantee: Lívia Araújo Alves
• Support Opportunities: Scholarships in Brazil - Doctorate