Competitive Host-guest Electrochemical Detection of Ivermectin Drug Using a beta-cyclodextrin/Graphene-based Electrode

Author(s)

Silva, Martin K. L. ; Simoes, Rafael P. ; Leao, Alcides L. ; Lapa, Rainer M. L. ; Rascon, Jesus ; Cesarino, Ivana

• Document type: Journal article
• Source: Electroanalysis; v. N/A, p. 13-pg., 2022-05-31.

Abstract

The present study describes the novel development and application of an ivermectin (IVM) sensing electrochemical platform based on reduced graphene oxide (rGO) and the macrocyclic host beta-cyclodextrin (beta-CD) molecule. The sensing method was based in the host-guest characteristics of beta-CD and competitive interaction between the target analyte and the methylene blue (MB) redox probe. Differential pulse voltammetry (DPV) was employed for the detection of IVM and a linear response between 0.5 and 40.0 mu mol L-1 with a limit of detection of 0.25 mu mol L-1 was obtained using the glassy carbon (GC)/rGO/beta-CD electrode. The sensing platform was successfully applied for the detection of IVM in tap water samples, which may expand the applications of beta-CD towards the analysis of other chemical species. (AU)

• FAPESP's process: 17/24274-3 - Development of glucose biosensor as an analytical tool aiming the optimization of second-generation ethanol production from pineapple residues
• Grantee: Ivana Cesarino
• Support Opportunities: Program for Research on Bioenergy (BIOEN) - Regular Program Grants