| Full text | |
| Author(s): |
Kinoshita, Paula Fernanda
;
Marques Orellana, Ana Maria
;
Nakao, Vinicius Watanabe
;
de Souza Port's, Natacha Medeiros
;
Menezes Quintas, Luis Eduardo
;
Kawamoto, Elisa Mitiko
;
Scavone, Cristoforo
Total Authors: 7
|
| Document type: | Journal article |
| Source: | British Journal of Pharmacology; v. 179, n. 8, p. 13-pg., 2021-03-30. |
| Abstract | |
Na+/K+-ATPase, a transmembrane protein essential for maintaining the electrochemical gradient across the plasma membrane, acts as a receptor for cardiotonic steroids such as ouabain. Cardiotonic steroids binding to Na+/K+-ATPase triggers signalling pathways or inhibits Na+/K+-ATPas activity in a concentration-dependent manner, resulting in a modulation of Ca2+ levels, which are essential for homeostasis in neurons. However, most of the pharmacological strategies for avoiding neuronal death do not target Na+/K+-ATPase activity due to its complexity and the poor understanding of the mechanisms involved in Na+/K+-ATPase modulation. The present review aims to discuss two points regarding the interplay between Na+/K+-ATPase and Ca2+ signalling in the brain. One, Na+/K+-ATPase impairment causing illness and neuronal death due to Ca2+ signalling and two, benefits to the brain by modulating Na+/K+-ATPase activity. These interactions play an essential role in neuronal cell fate determination and are relevant to find new targets for the treatment of neurodegenerative diseases. (AU) | |
| FAPESP's process: | 16/22996-9 - Evaluation of physical exercise effects on cognition of neuronal-PTEN deleted animals |
| Grantee: | Elisa Mitiko Kawamoto Iwashe |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/14289-6 - The role of Klotho protein in Alzheimer's disease |
| Grantee: | Paula Fernanda Kinoshita |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/07427-8 - Aging and neuroprotection: effects of Klotho protein in energetic metabolism, Na,K-ATPase signaling and adaptative response in central nervous system |
| Grantee: | Cristoforo Scavone |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 19/12974-6 - Evaluation of PTEN inhibition and compartmentalization effects in the presence of neuroinflammation: participation of glutamatergic signaling |
| Grantee: | Elisa Mitiko Kawamoto Iwashe |
| Support Opportunities: | Regular Research Grants |