Trophoblast cell surface antigen 2 expression predicts outcome in oral squamous cell carcinomas

Author(s)

Dourado, Mauricio Rocha ; Machado, Renato Assis ; Paranaiba, Livia Maris Ribeiro ; Gonzalez-Arriagada, Wilfredo Alejandro ; da Silva, Sabrina Daniela ; Sawazaki-Calone, Iris ; Graner, Edgard ; Salo, Tuula ; Coletta, Ricardo D.

• Document type: Journal article
• Source: ORAL DISEASES; v. 28, n. 4, p. 9-pg., 2021-03-05.

Abstract

Background Trophoblast cell surface antigen 2 (TROP2) has unclear clinical role in oral squamous cell carcinomas (OSCC). Here, we investigated the association of TROP2 immunoexpression with clinicopathological parameters and survival of OSCC patients. Subjects and Methods Cancer-specific survival (CSS) and disease-free survival (DFS) were assessed in a cohort composed of 266 OSCC. An independent cohort with 88 OSCC samples matched with the normal oral tissue, as well as 17 metastatic lymph nodes, was used for validation. Results Multivariate analysis showed TROP2 as an independent marker of favorable prognosis for both CSS (HR: 0.60, 95% CI: 0.40-0.90, p = .01) and DFS (HR: 0.57, 95% CI: 0.36-0.89, p = .01). Furthermore, TROP2 protein expression was significantly higher in morphologically normal tissues compared to primary tumors (p < .0001) and lymph node metastases (p = .001), and it was significantly associated with CSS (HR: 0.26, 95% CI: 0.09-0.74, p = .008) in the validation cohort. A pooled mRNA analysis performed on the Oncomine (TM) database confirmed the underexpression in OSCC compared with normal tissues (p = .014). Conclusions In summary, our results point to a favorable prognostic significance of TROP2 overexpression in a large cohort of oral cancer patients, suggesting it as an attractive clinical marker. (AU)

• FAPESP's process: 17/26764-8 - The prognostic value and biological role of overexpressed proteins in oral squamous cell carcinoma identified by mass spectrometry-based proteomic
• Grantee: Mauricio da Rocha Dourado
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 18/16077-6 - The prognostic value and biological role of overexpressed proteins in oral squamous cell carcinoma identified by mass spectrometry-based proteomic
• Grantee: Ricardo Della Coletta
• Support Opportunities: Regular Research Grants