Clinical predictors of malignant transformation and recurrence in oral potentially malignant disorders: A systematic review and meta-analysis

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Paglioni, Mariana de Pauli ; Khurram, Syed Ali ; Ruiz, Blanca Iciar Indave ; Lauby-Secretan, Beatrice ; Normando, Ana Gabriela ; Prado Ribeiro, Ana Carolina ; Brandao, Thais Bianca ; Palmier, Natalia Rangel ; Lopes, Marcio Ajudarte ; da Silva Guerra, Eliete Neves ; Meleti, Marco ; Migliorati, Cesar Augusto ; Carvalho, Andre Lopes ; de Matos, Leandro Luongo ; Kowalski, Luiz Paulo ; Santos-Silva, Alan Roger

• Document type: Journal article
• Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 134, n. 5, p. 15-pg., 2022-11-28.

Abstract

Objective. We performed a systematic review dedicated to pooling evidence for the associations of clinical features with malignant transformation (MT) and recurrence of 3 oral potentially malignant disorders (OPMDs) (actinic cheilitis [AC], oral leukoplakia [OL], and proliferative verrucous leukoplakia [PVL]). Study Design. We selected studies that included clinical features and risk factors (age, sex, site, size, appearance, alcohol intake, tobacco use, and sun exposure) of OL, PVL, and AC associated with recurrence and/or MT. Results. Based on the meta-analysis results, non-homogeneous OL appears to have a 4.53 times higher chance of recurrence after treatment. We also found 6.52 higher chances of MT of non-homogeneous OL. Another clinical feature related to higher MT chances is the location (floor of the mouth and tongue has 4.48 higher chances) and the size (OL with >200 mm2 in size has 4.10 higher chances of MT). Regarding habits, nonsmoking patients with OL have a 3.20 higher chance of MT. The only clinical feature related to higher chances of MT in patients with PVL was sex (females have a 2.50 higher chance of MT). Conclusions. Our study showed that some clinical features may indicate greater chances of recurrence after treatment and MT of OPMD. (AU)

• FAPESP's process: 18/04657-8 - Salivary protein markers of radiation-related oral toxicites
• Grantee: Natália Rangel Palmier
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/06138-1 - A prospective study of radiation-induced trismus in patients with oral squamous cell carcinoma
• Grantee: Ana Carolina Prado Ribeiro e Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/02233-6 - Oncological safety of the use of intraoral and extraoral photobiomodulation in patients with oral cavity and oropharyngeal squamous cell carcinoma
• Grantee: Alan Roger dos Santos Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/18402-8 - Evaluation of the direct effects of radiation on the enamel, dentin and dental pulp of head and neck cancer patients
• Grantee: Alan Roger dos Santos Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/22862-2 - Impact of age in radiation-induced oral toxicities of young patients with oral cancer
• Grantee: Jaqueline de Lima Correia
• Support Opportunities: Scholarships in Brazil - Scientific Initiation