Cold Atmospheric Plasma as a Therapeutic Tool in Medicine and Dentistry

Author(s)

Koga-Ito, Cristiane Yumi ; Kostov, K. G. ; Miranda, F. S. ; Milhan, N. V. M. ; Neto, N. F. Azevedo ; Nascimento, F. ; Pessoa, R. S.

• Document type: Journal article
• Source: PLASMA CHEMISTRY AND PLASMA PROCESSING; v. N/A, p. 37-pg., 2023-08-27.

Abstract

This comprehensive review explores decade-long research conducted on the applications of Cold Atmospheric Plasma (CAP) and Plasma Activated Liquids (PAL), including Plasma Activated Water (PAW), in the fields of Medicine and Dentistry. CAPs, operating at atmospheric pressure, offer unique advantages over conventional medical devices, generating Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) that interact with substances, enabling diverse applications. The review examined CAP and PAL efficacy against infectious diseases using in vitro, ex vivo, in vivo, and direct application methods. Significant strides were observed in wound healing, cancer treatment, and dental care. However, ensuring patient safety through rigorous plasma source standards remains crucial. The study underscores CAPs and PALs' potential to transform medical and dental therapies, urging further research and development in these groundbreaking technologies. These findings highlight the transformative impact of CAPs and PALs, offering promising avenues for innovative medical and dental treatments. (AU)

• FAPESP's process: 16/07196-6 - Prospection of innovative therapeutic alternatives for infectious diseases with relevance in Dentistry: low temperature atmospheric pressure plasma and nanoencapsulate of bioactive substance
• Grantee: Cristiane Yumi Koga Ito
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/14181-3 - Development and study of a plasma system generated by dielectric barrier discharge (DBD) for continuous activation of liquids applied in dental treatments
• Grantee: Felipe de Souza Miranda
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 23/02268-2 - Generation and characterization of different liquids activated with plasma for use in endodontic treatment
• Grantee: Nilton Francelosi Azevedo Neto
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 19/05856-7 - Use of low temperature atmospheric pressure plasma in dentistry: from laboratory bench to clinics
• Grantee: Cristiane Yumi Koga Ito
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 20/09481-5 - Applications of non-thermal atmospheric plasmas in Dentistry: from the bench to the clinic
• Grantee: Fellype do Nascimento
• Support Opportunities: Scholarships in Brazil - Post-Doctoral