Bypass gastroplasty impacts oral health, salivary inflammatory biomarkers, and microbiota: a controlled study

Author(s)

Ribeiro, Aianne Souto Pizzolato ; Marquezin, Maria Carolina Salome ; Pacheco, Elisane Rossin Pessotti ; Rasera Jr, Irineu ; Klein, Marlise Ines ; de Vasconcellos, Suzan Pantaroto ; Landgraf, Richardt Gama ; Okamoto, Debora ; Calixto, Leandro Augusto ; Castelo, Paula Midori

• Document type: Journal article
• Source: CLINICAL ORAL INVESTIGATIONS; v. 27, n. 8, p. 12-pg., 2023-06-09.

Abstract

ObjectivesKnowledge about the impact of gastroplasty on oral health and salivary biomarkers is limited. The aim was to prospectively evaluate oral health status, salivary inflammatory markers, and microbiota in patients undergoing gastroplasty compared with a control group undergoing a dietary program.Materials and methodsForty participants with obesity class II/III were included (20 individuals in each sex-matched group; 23-44 years). Dental status, salivary flow, buffering capacity, inflammatory cytokines, and uric acid were assessed. Salivary microbiological analysis (16S-rRNA sequencing) assessed the abundance of genus, species, and alpha diversity. Cluster analysis and mixed-model ANOVA were applied.ResultsOral health status, waist-to-hip ratio, and salivary alpha diversity were associated at baseline. A subtle improvement in food consumption markers was observed, although caries activity increased in both groups, and the gastroplasty group showed worse periodontal status after three months. IFN gamma and IL10 levels decreased in the gastroplasty group at 3 months, while a decrease was observed in the control group at 6 months; IL6 decreased in both groups (p < 0.001). Salivary flow and buffering capacity did not change. Significant changes in Prevotella nigrescens and Porphyromonas endodontalis abundance were observed in both groups, while alpha diversity (Sobs, Chao1, Ace, Shannon, and Simpson) increased in the gastroplasty group.ConclusionsBoth interventions changed in different degrees the salivary inflammatory biomarkers and microbiota, but did not improve the periodontal status after 6 months. (AU)

• FAPESP's process: 20/16020-4 - Role of high concentration of maternal corticosterone and possible epigenetic changes in acute lung inflammation of low birth weight rats
• Grantee: Richardt Gama Landgraf
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/10940-9 - Impact of gastroplasty on salivary composition and cytomorphology of oral mucosa: follow-up three and six months
• Grantee: Maria Carolina Salomé Marquezin
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 17/26400-6 - Impact of gastroplasty on salivary composition and cytomorphology of oral mucosa: follow-up three and six months
• Grantee: Paula Midori Castelo Ferrua
• Support Opportunities: Regular Research Grants