Biocompatibility, bioactive potential, porosity, and interface analysis calcium silicate repair cements in a dentin tube model

Author(s)

Inada, Rafaela Nanami Handa ; Queiroz, Marcela Borsatto ; Lopes, Camila Soares ; Silva, Evelin Carine Alves ; Torres, Fernanda Ferrari Esteves ; da Silva, Guilherme Ferreira ; Guerreiro-Tanomaru, Juliane Maria ; Cerri, Paulo Sergio ; Tanomaru-Filho, Mario

• Document type: Journal article
• Source: CLINICAL ORAL INVESTIGATIONS; v. 27, n. 7, p. 15-pg., 2023-04-04.

Abstract

ObjectivesThis study is to evaluate biocompatibility, bioactive potential, porosity, and dentin/material interface of Bio-C Repair (BIOC-R), MTA Repair HP (MTAHP), and Intermediate Restorative Material (IRM).Materials and methodsDentin tubes were implanted into subcutaneous of rats for 7, 15, 30, and 60 days. Thickness of capsules, number of inflammatory cells (ICs), interleukin-6 (IL-6), osteocalcin (OCN), and von Kossa were evaluated. Porosity and material/dentin interface voids were also analyzed. Data were submitted to ANOVA and Tukey's tests (p < 0.05).ResultsIRM capsules were thicker and contained greater ICs and IL-6-immunopositive cells at 7 and 15 days. BIOC-R capsules exhibited higher thickness and ICs at 7 days and greater IL-6 at 7 and 15 days than MTAHP (p < 0.05). At 30 and 60 days, no significant difference was observed among the groups. OCN-immunopositive cells, von Kossa-positive, and birefringent structures were observed in BIOC-R and MTAHP. MTAHP exhibited higher porosity and interface voids (p < 0.05).ConclusionsBIOC-R, MTAHP, and IRM are biocompatible. Bioceramics materials demonstrate bioactive potential. MTAHP presented the highest porosity and presence of voids. (AU)

• FAPESP's process: 17/14305-9 - Evaluation of new substances for root canal irrigation and calcium silicate-based endodontic sealers
• Grantee: Juliane Maria Guerreiro Tanomaru
• Support Opportunities: Regular Research Grants
• FAPESP's process: 17/19049-0 - Evaluation of the root canal treatment procedures, physicochemical and biological properties of tricalcium silicate-based materials
• Grantee: Mario Tanomaru Filho
• Support Opportunities: Regular Research Grants