Study on the photophysical property of meso-tetra(2-fluorenyl)porphyrin derivatives and their interactions with DNA/HSA biomacromolecules

Author(s)

Tisoco, Isadora ; Kohler, Mateus H. ; Nogara, Pablo A. ; Rocha, Joao B. T. ; do Nascimento, Carolina S. ; Garcia, Rafael de Q. ; De Boni, Leonardo ; Iglesias, Bernardo A.

• Document type: Journal article
• Source: Inorganica Chimica Acta; v. 556, p. 13-pg., 2023-06-17.

Abstract

A classical approach is reported to design tetra-substituted porphyrins and corresponding transition metal Zn(II) derivative. These porphyrins were characterized by HRMS mass analysis, UV-Vis absorption, immobilization and time-resolved fluorescence emission, theoretical DFT calculations, and electrochemical techniques. Photobiological parameters such as photostability and singlet oxygen-producing species were also assessed. Finally, spectroscopic and viscometer studies and molecular docking calculations revealed the ability of each porphyrin derivative to interact with calf thymus DNA and human serum albumin. (AU)

• FAPESP's process: 20/16036-8 - Ultrafast spectroscopy: degenerated and non-degenerated pump-probe resolved in polarization
• Grantee: Rafael de Queiroz Garcia
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 22/02439-9 - Ultrafast coherent spectroscopy in the sub-100 fs regime
• Grantee: Rafael de Queiroz Garcia
• Support Opportunities: Scholarships abroad - Research Internship - Master's degree
• FAPESP's process: 16/20886-1 - Ultrafast nonlinear optical spectroscopy: Transient Absorption and optical Kerr Gate with polarization control
• Grantee: Leonardo de Boni
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/11283-7 - Nonlinear photonics: spectroscopy and advanced processing of materials
• Grantee: Cleber Renato Mendonça
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/03758-5 - Assemblage of an experimental line of Laser Induced Breakdown Spectroscopy (LIBS) with femtosecond pulses
• Grantee: Rafael de Queiroz Garcia
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 22/06561-3 - 6th International Workshop on Nano and Biophotonics
• Grantee: Leonardo de Boni
• Support Opportunities: Research Grants - Meeting - Abroad
• FAPESP's process: 22/06528-6 - Optical spectroscopic studies and triplet quantum yield determination in Tetraphenyl Porphyrins free base derivatives with distinct Chalcones side groups
• Grantee: Carolina Salgado do Nascimento
• Support Opportunities: Scholarships in Brazil - Scientific Initiation