Transdermal delivery systems for migraine treatment: A gap to explore

Author(s)

Sueiro, Ana Claudia ; dos Santos, Erica Mendes ; Tundisi, Louise Lacalendola ; Masquetti Fava, Ana Laura ; Luna Silverio, Luiza Aparecida ; Coco, Julia Cedran ; Ataide, Janaina Artem ; Paiva-Santos, Ana Claudia ; Mazzola, Priscila Gava

• Document type: Journal article
• Source: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 77, p. 8-pg., 2022-11-02.

Abstract

Migraine is one of the most common forms of headache and affects approximately 15% of the world's population, and it is considered a disabling disease. There are several treatments to control migraine pain and symptoms, and the most common pharmaceutical form used is oral tablets. Oral treatment during acute migraine attacks is not fully effective because of its associated symptoms, such as nausea and vomiting, and oral administration of actives also limits bioavailability. Transdermal formulations are a promising alternative for the administration of these actives, as they can considerably improve the bioavailability and efficacy of the treatment, without the inconvenience of invasive treatments. Thus, this article reviews transdermal delivery systems for migraine, emphasizing advantages, as promising technological strategies for effective, comfortable, and strong adhesion promoters to migraine treatment, presenting studies available in the area, as well as the lack of drugs available on the market for transdermal delivery. (AU)

• FAPESP's process: 18/06475-4 - Development of pharmaceutical formulation for burns' healing
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