| Full text | |
| Author(s): |
Ballestero, Matheus
;
Doria, Anelise C. O. C.
;
Pessoa, Rodrigo S.
;
Rodrigues, Bruno V. M.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Materials Letters; v. 344, p. 5-pg., 2023-04-25. |
| Abstract | |
Catheter-associated infections are a concern in healthcare and the leading cause of hospital-acquired infections, which can be caused by a variety of microorganisms, including bacteria and fungi. To prevent severe complications, developing materials with antimicrobial and/or microbiostatic properties is critical. Atomic layer deposition (ALD) is a thin-film deposition technique that precisely controls the thickness and composition of deposited metallic oxide films. ALD is promising for creating biomedical devices, drug delivery systems, and tissue engineering scaffolds with complex geometries. Given the microbiostatic properties of some metallic oxides-coatings, which act hampering the adherence of microorganisms, this work investigated the ALD of Al2O3 thin films on the surface and lumen of silicone catheters. Herein, we showed that Al2O3-coated silicone catheters with a thickness of 100 nm inhibited the formation of biofilm towards Staphylococcus aureus, Escherichia coli and Candida albicans, while reducing the contamination by 1 Log. The low temperature ALD approach presented in this investigation paves the way for further studies on active coatings aiming at biomedical devices with improved microbiostatic properties towards different microorganisms. (AU) | |
| FAPESP's process: | 20/08485-7 - Silicone catheters modified via atomic layer deposition technique for neurosurgical applications |
| Grantee: | Anelise Cristina Osorio Cesar Doria |
| Support Opportunities: | Scholarships in Brazil - Innovative Research in Small Business - PIPE |
| FAPESP's process: | 18/01265-1 - Synthesis and microbiological analysis of polymer substrates coated with TiO2 and / or Al2O3 ultra-thin films by atomic layer deposition technology |
| Grantee: | Rodrigo Savio Pessoa |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 19/16685-9 - Silicone catheters modified by atomic layer deposition for neurosurgical applications |
| Grantee: | Anelise Cristina Osorio Cesar Doria |
| Support Opportunities: | Research Grants - Innovative Research in Small Business - PIPE |