| Full text | |
| Author(s): |
Ataide, Vanessa N.
;
Pradela-Filho, Lauro A.
;
Ameku, Wilson A.
;
Negahdary, Masoud
;
Oliveira, Thawan G.
;
Santos, Berlane G.
;
Paixao, Thiago R. L. C.
;
Angnes, Lucio
Total Authors: 8
|
| Document type: | Journal article |
| Source: | Microchimica Acta; v. 190, n. 7, p. 17-pg., 2023-07-01. |
| Abstract | |
Paper-based electrochemical analytical devices (ePADs) have gained significant interest as promising analytical units in recent years because they can be fabricated in simple ways, are low-cost, portable, and disposable platforms that can be applied in various fields. In this sense, paper-based electrochemical biosensors are attractive analytical devices since they can promote diagnose several diseases and potentially allow decentralized analysis. Electrochemical biosensors are versatile, as the measured signal can be improved by using mainly molecular technologies and nanomaterials to attach biomolecules, resulting in an increase in their sensitivity and selectivity. Additionally, they can be implemented in microfluidic devices that drive and control the flow without external pumping and store reagents, and improve the mass transport of analytes, increasing sensor sensitivity. In this review, we focus on the recent developments in electrochemical paper-based devices for viruses' detection, including COVID-19, Dengue, Zika, Hepatitis, Ebola, AIDS, and Influenza, among others, which have caused impacts on people's health, especially in places with scarce resources. Also, we discuss the advantages and disadvantages of the main electrode's fabrication methods, device designs, and biomolecule immobilization strategies. Finally, the perspectives and challenges that need to be overcome to further advance paper-based electrochemical biosensors' applications are critically presented. (AU) | |
| FAPESP's process: | 19/22126-2 - Electrochemical behavior of carbonic acid hemiesters in aqueous medium |
| Grantee: | Berlane Gomes Santos |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 18/16896-7 - Development of amperometric and impedimetric sensors based on double hydroxides of nickel and vanadium (alpha-NixV1-x(OH)2) and their nanocomposites with expandable graphite/graphene |
| Grantee: | Josué Martins Gonçalves |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/08782-1 - Miniaturized and integrated chemical sensors: new fabrication platforms for biological, clinical and environmental applications |
| Grantee: | Mauro Bertotti |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis |
| Grantee: | Marco Aurelio Zezzi Arruda |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 21/00205-8 - Miniaturized and/or microfluidic analytical devices for biological applications |
| Grantee: | Lauro Antonio Pradela Filho |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/14462-0 - Fabrication of electrochemical paper-based device aiming clinical and environmental applications |
| Grantee: | Vanessa Neiva de Ataide |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 17/13137-5 - Formation and properties of hemiesters of carbonic acid in aqueous medium |
| Grantee: | Claudimir Lucio Do Lago |
| Support Opportunities: | Research Projects - Thematic Grants |