Recent Advances in Greener Asymmetric Organocatalysis Using Bio-Based Solvents

Author(s)

Martelli, Lorena S. R. ; Machado, Ingrid V. V. ; dos Santos, Jhonathan R. N. ; Correa, Arlene G. G.

• Document type: Journal article
• Source: CATALYSTS; v. 13, n. 3, p. 52-pg., 2023-03-01.

Abstract

Efficient synthetic methods that avoid the extensive use of hazardous reagents and solvents, as well as harsh reaction conditions, have become paramount in the field of organic synthesis. Organocatalysis is notably one of the best tools in building chemical bonds between carbons and carbon-heteroatoms; however, most examples still employ toxic volatile organic solvents. Although a portfolio of greener solvents is now commercially available, only ethyl alcohol, ethyl acetate, 2-methyltetrahydrofuran, supercritical carbon dioxide, ethyl lactate, and diethyl carbonate have been explored with chiral organocatalysts. In this review, the application of these bio-based solvents in asymmetric organocatalytic methods reported in the last decade is discussed, highlighting the proposed mechanism pathway for the transformations. (AU)

• FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
• Grantee: Arlene Gonçalves Corrêa
• Support Opportunities: Research Grants - Research Centers in Engineering Program
• FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
• Grantee: Glaucius Oliva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 18/23761-0 - Stereoselective synthesis of heterocycles from the opening of chiral epoxides or azidirines
• Grantee: Lorena Suelen Ribeiro Martelli
• Support Opportunities: Scholarships in Brazil - Doctorate