| Full text | |
| Author(s): |
Silveira, Heitor Albergoni
;
Ragusa Silva, Paula Verona
;
Pimentel, Bruna Goncalves
;
Nogueira, Gustavo Milhomens
;
Chahud, Fernando
;
Brunaldi, Mariangela Ottoboni
;
Leon, Jorge Esquiche
Total Authors: 7
|
| Document type: | Journal article |
| Source: | AMERICAN JOURNAL OF DERMATOPATHOLOGY; v. 45, n. 5, p. 4-pg., 2023-05-01. |
| Abstract | |
Lymphomatoid papulosis (LyP) belongs to the spectrum of primary cutaneous CD30(+) lymphoproliferative disorders, characterized by chronic, recurrent, self-healing papules, small nodules, or ulcers. The clinicopathological features of LyP can mimic overt lymphomas. To date, about 27 intraoral LyP cases have been reported. Of them, only 2 cases were diagnosed as angioinvasive LyP (type E). Herein, we report a 24-year-old Brazilian man who presented a large ulcerated lesion on the hard palate with rapid evolution. Remarkably, there was no involvement of the skin or other mucous membranes. Microscopy revealed a lymphoid infiltrate constituted by medium-sized to large atypical cells, with angiocentric and angiodestructive features. The atypical cells showed immunopositivity for CD3, CD8, CD30, CD56, granzyme B, perforin, and focally for MUM1/IRF4. Ki-67 highlighted almost all atypical lymphoid cells, whereas EBER1/2 was negative. After 2 months of follow-up, the lesion healed completely. Although rare, LyP type E should be included in the differential diagnosis of oral ulcers. (AU) | |
| FAPESP's process: | 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma |
| Grantee: | Heitor Albergoni da Silveira |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 08/50287-6 - Estudo clinicopatológico, imuno-histoquímico, hibridização in situ e ploidia do DNA de linfomas não-Hodgkin na região de cabeça e pescoço em diferentes populações latinoamericanas |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region. |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 22/12760-9 - Clinicopathological correlation of the immune system, cell differentiation, angiogenesis, lipid metabolism and transcriptionally active HPV in a large series of head and neck squamous cell carcinomas |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Regular Research Grants |