The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women

Author(s)

Solis, Marina Yazigi ; Artioli, Guilherme Giannini ; Montag, Eduardo ; Painelli, Vitor de Salles ; Saito, Fabio Lopes ; Lima, Fernanda Rodrigues ; Roschel, Hamilton ; Gualano, Bruno ; Lancha Junior, Antonio Herbert ; Benatti, Fabiana Braga

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY; v. 2014, p. 6-pg., 2014-01-01.

Abstract

It has been suggested that the abrupt liposuction-induced decrease in adipose tissue could affect adipokine secretion pattern. We hypothesized that exercise training could positively impact adipokine metabolism following liposuction. The aim of this study was to investigate the effects of liposuction on inflammation-related adipokines in women who were either exercise-trained or remained sedentary after surgery. Thirty-six healthy normal-weight women underwent an abdominal liposuction and two months after surgery were randomly allocated into two groups: trained (TR, n = 18, four-month exercise program) and nontrained (NT, n = 18). Inflammation-related adipokine serum levels (TNF-alpha, IL-6, IL-10, and adiponectin) and abdominal and thigh subcutaneous adipose tissue (scAT) mRNA levels were assessed before (PRE) and six months after surgery (POST6). TNF-alpha, IL-6, and IL-10 serum levels were unchanged in both groups. In contrast, TNF-alpha, IL-6, and IL-10 mRNA levels in scAT were increased, whereas adiponectin scAT mRNA and serum levels were decreased at POST6 (P < 0.05, main effect for time). No changes were observed in mRNA levels of MCP-1, CD14, and CD68 in any of the groups. In conclusion, liposuction downregulates adiponectin scAT gene expression and serum levels and upregulates scAT gene expression of inflammation-related genes six months after surgery in normal-weight women, irrespective of exercise training. (AU)

• FAPESP's process: 13/04806-0 - Effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations
• Grantee: Vitor de Salles Painelli
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/07319-0 - Effect of an alimentary supplement used in order to improve bone mineral density
• Grantee: Antonio Herbert Lancha Junior
• Support Opportunities: Scholarships abroad - Research
• FAPESP's process: 11/08302-0 - Effects of chronic aerobic training on the insulin sensitivity of patients with systemic lupus erythematosus
• Grantee: Fabiana Braga Benatti
• Support Opportunities: Scholarships in Brazil - Post-Doctoral