| Full text | |
| Author(s): |
Pimentel, Gustavo D.
;
Ganeshan, Kirthana
;
Carvalheira, Jose B. C.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | Molecular and Cellular Endocrinology; v. 397, n. 1-2, p. 8-pg., 2014-11-25. |
| Abstract | |
The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states. (C) 2014 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 13/01649-0 - Characterization of hypothalamic AMPK in tumoral development and inflammatory central and systemic process in rodents |
| Grantee: | Gustavo Duarte Pimentel |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 11/02806-7 - Characterization of the hypothalamic AMPK/mTOR in cancer-induced anorexia |
| Grantee: | Gustavo Duarte Pimentel |
| Support Opportunities: | Scholarships in Brazil - Doctorate |