| Full text | |
| Author(s): Show less - |
Oliveira, Denise Tostes
;
Bravo-Calderon, Diego Mauricio
;
Lauand, Gustavo Amaral
;
Assao, Agnes
;
Suarez-Penaranda, Jose-Manuel
;
Perez-Sayans, Mario
;
Garcia-Garcia, Abel
;
Marana, Aparecido Nilceu
;
Nonogaki, Suely
;
Pereira Lauris, Jose Roberto
;
Kowalski, Luiz Paulo
Total Authors: 11
|
| Document type: | Journal article |
| Source: | JOURNAL OF ONCOLOGY; v. 2016, p. 8-pg., 2016-01-01. |
| Abstract | |
Background. The beta-2 adrenergic receptor is expressed by neoplastic cells and is correlated with a wide spectrum of tumor cell mechanisms including proliferation, apoptosis, angiogenesis, migration, and metastasis. Objectives. The present study aimed to analyze the expression of the beta-2 adrenergic receptor (beta 2-AR) in tumor-free surgical margins of oral squamous cell carcinomas (OSCC) and at the invasive front. Sixty-two patients diagnosed with OSCC, confirmed by biopsy, were selected for the study. The clinicopathological data and clinical follow-up were obtained from medical records and their association with beta 2-AR expression was verified by the chi-square test or Fischer's exact test. To verify the correlation of beta 2-AR expression in tumor-free surgical margins and at the invasive front of OSCCs, Pearson's correlation coefficient test was applied. Results. The expression of beta 2-AR presented a statistically significant correlation between the tumor-free surgical margins and the invasive front of OSCC (p = 0.383; p = 0.002). The immunohistochemical distribution of beta 2-AR at the invasive front of OSCC was also statistically significant associated with alcohol (p = 0.038), simultaneous alcohol and tobacco consumption (p = 0.010), and T stage (p = 0.014). Conclusions. The correlation of beta 2-AR expression in OSCC and tumor-free surgical margins suggests a role of this receptor in tumor progression and its expression in normal oral epithelium seems to be constitutive. (AU) | |
| FAPESP's process: | 11/11630-0 - Comparison of beta-2-adrenergic receptor in the surgical margins of oral mucosa and malignant cells of oral squamous cell carcinoma |
| Grantee: | Gustavo Amaral Lauand |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 12/04098-2 - Expression of beta-2 adrenergic receptor in frozen tissues of the oral squamous cell carcinomas |
| Grantee: | Gustavo Amaral Lauand |
| Support Opportunities: | Scholarships abroad - Research Internship - Scientific Initiation |