Expression of beta-2 adrenergic receptor in frozen tissues of the oral squamous cell carcinomas

• Grant number: 12/04098-2
• Support type: Scholarships abroad - Research Internship - Scientific Initiation
• Effective date (Start): June 01, 2012
• Effective date (End): July 31, 2012
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal researcher: Denise Tostes Oliveira
• Grantee: Gustavo Amaral Lauand
• Supervisor abroad: José Manuel Suárez Peñaranda
• Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil
• Research place: Universidade de Santiago de Compostela, Santiago (USC), Spain
• Associated to the scholarship: 11/11630-0 - Comparison of beta-2-adrenergic receptor in the surgical margins of oral mucosa and malignant cells of oral squamous cell carcinoma, BP.IC

Abstract

This study is designed to verify the immunohistochemical expression of ²2-adrenergic receptor (²2-AR) in the malignant cells of fresh tumor specimens of oral squamous cell carcinomas (OSCC) and in the oral epithelium adjacent to the tumor, with the aim to compare and confirm the immunohistochemical expression previously verified in paraffin-embedded samples of OSCC. Fresh OSCC samples (n=15) frozen at - 20 °C will be analyzed for the ²2-AR expression in the epithelial cells of the oral mucosa and neoplastic cells of the OSCC. Microscopic fields of the invasion tumor front will be captured with a camera integrated to light microcopy at 400 X magnification. The ²2-AR immunohistochemical expression by neoplastic cell of each microscopic field will be analyzed and compared to images of OSCC obtained from paraffin-embedded samples previously investigated for Bravo-Calderón et al (2011). (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

OLIVEIRA, DENISE TOSTES; BRAVO-CALDERON, DIEGO MAURICIO; LAUAND, GUSTAVO AMARAL; ASSAO, AGNES; SUAREZ-PENARANDA, JOSE-MANUEL; PEREZ-SAYANS, MARIO; GARCIA-GARCIA, ABEL; MARANA, APARECIDO NILCEU; NONOGAKI, SUELY; PEREIRA LAURIS, JOSE ROBERTO; KOWALSKI, LUIZ PAULO. Correlation of Beta-2 Adrenergic Receptor Expression in Tumor-Free Surgical Margin and at the Invasive Front of Oral Squamous Cell Carcinoma. JOURNAL OF ONCOLOGY, 2016. Web of Science Citations: 0.