| Full text | |
| Author(s): |
Souza, Maykon Lima
;
Roveda, Antonio Carlos, Jr.
;
Melo Pereira, Jose Clayston
;
Franco, Douglas Wagner
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Coordination Chemistry Reviews; v. 306, p. 13-pg., 2016-01-01. |
| Abstract | |
The susceptibility of the nitrosonium ligand (NO+) of metal nitrosyls to nucleophilic attack has been reviewed. The reactions of nitroprusside with thiolate (RS-) nucleophiles (H2S, cysteine, glutathione, N-acetylcysteine and others) have been covered, albeit the main focus is on the reactivity of ruthenium nitrosyl ammines (trans-[Ru(NH3)(4)(L)NO+](n+)) with cysteine and glutathione. Kinetic aspects and reaction products are discussed. Nitric oxide (NO) and nitroxyl (HNO) are the primary and main nitrogen-based products of the reactions with RS-. The final nitrogen based product N2O is identified and suggested as the direct product from the dimerization reaction of HNO. The accumulated data strongly suggest that the ratio of [NO]/[HNO] formed is dependent on the [RS-]/[RSH] ratio, which can be controlled by the experimental conditions. Some aspects of thiol-responsive nitric oxide-releasing materials are also discussed. (C) 2015 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 12/23651-4 - Nitrosyl and nitroxyl as ligands on Ru(II): synthesis, kinetics, reactivity and thermodynamics |
| Grantee: | Douglas Wagner Franco |
| Support Opportunities: | Regular Research Grants |