Insulin Resistance Predicts Atherogenic Lipoprotein Profile in Nondiabetic Subjects

Author(s)

Cartolano, Flavia De C. ; Dias, Gabriela D. ; de Freitas, Maria C. P. ; Figueiredo Neto, Antonio M. ; Damasceno, Nagila R. T.

• Document type: Journal article
• Source: JOURNAL OF DIABETES RESEARCH; v. 2017, p. 8-pg., 2017-01-01.

Abstract

Background. Atherogenic diabetes is associated with an increased cardiovascular risk and mortality in diabetic individuals; however, the impact of insulin resistance (IR) in lipid metabolism in preclinical stages is generally underreported. For that, we evaluated the capacity of IR to predict an atherogenic lipid subfraction profile. Methods. Complete clinical evaluation and biochemical analysis (lipid, glucose profile, LDL, and HDL subfractions and LDL phenotype and size) were performed in 181 patients. The impact of IR as a predictor of atherogenic lipoproteins was tested by logistic regression analysis in raw and adjusted models. Results. HDL-C and Apo AI were significantly lower in individuals with IR. Individuals with IR had a higher percentage of small HDL particles, lower percentage in the larger ones, and reduced frequency of phenotype A (IR = 62%; non-IR = 83%). IR individuals had reduced probability to have large HDL (OR = 0.213; CI = 0.999-0.457) and had twice more chances to show increased small HDL (OR = 2.486; CI = 1.341-7.051). IR was a significant predictor of small LDL (OR = 3.075; CI = 1.341-7.051) and atherogenic phenotype (OR = 3.176; CI = 1.469-6.867). Conclusion. IR, previously DM2 diagnosis, is a strong predictor of quantitative and qualitative features of lipoproteins directly associated with an increased atherogenic risk. (AU)

• FAPESP's process: 08/57685-7 - NICT of Complex Fluids (IFCx)
• Grantee: Antonio Martins Figueiredo Neto
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 15/06222-0 - Association between leptin and adponectin with antioxidant capacity of high density lipoprotein in individuals with Diabetes Mellitus
• Grantee: Gabriela Duarte Dias
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 11/13616-4 - Optical and structural properties of elastomers and complex fluids of biological interest
• Grantee: Antonio Martins Figueiredo Neto
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 11/12523-2 - Physical and chemical properties of LDL and HDL, cardiometabolic and oxidative markers can be modulate by consumption of ômega-3, ômega-6 e ômega-9 in adult subjects?
• Grantee: Nágila Raquel Teixeira Damasceno
• Support Opportunities: Regular Research Grants