Novel Nanotechnology of TiO2 Improves Physical-Chemical and Biological Properties of Glass Ionomer Cement

Author(s)

Cibim, Daniela Dellosso ; Saito, Miki Taketomi ; Giovani, Priscila Alves ; Sanches Borges, Ana Flavia ; Arias Pecorari, Vanessa Gallego ; Gomes, Orisson Ponce ; Lisboa-Filho, Paulo Noronha ; Nociti-Junior, Francisco Humberto ; Puppin-Rontani, Regina Maria ; Kantovitz, Kamila Rosamilia

• Document type: Journal article
• Source: INTERNATIONAL JOURNAL OF BIOMATERIALS; v. 2017, p. 11-pg., 2017-01-01.

Abstract

The aim of this study was to assess the performance of glass ionomer cement (GIC) added with TiO2 nanotubes. TiO2 nanotubes [3%, 5%, and 7%(w/w)] were incorporated into GIC's (Ketac Molar EasyMix (TM)) powder component, whereas unblended powder was used as control. Physical-chemical-biological analysis included energy dispersive spectroscopy (EDS), surface roughness (SR), Knoop hardness (SH), fluoride-releasing analysis, cytotoxicity, cell morphology, and extracellular matrix (ECM) composition. Parametric or nonparametric ANOVA were used for statistical comparisons (alpha <= 0.05). Data analysis revealed that EDS only detected Ti at the 5% and 7% groups and that GIC's physical-chemical properties were significantly improved by the addition of 5% TiO2 as compared to 3% and GIC alone. Furthermore, regardless of TiO2 concentration, no significant effect was found on SR, whereas GIC-containing 7% TiO2 presented decreased SH values. Fluoride release lasted longer for the 5% and 7% TiO2 groups, and cell morphology/spreading and ECM composition were found to be positively affected by TiO2 at 5%. In conclusion, in the current study, nanotechnology incorporated in GIC affected ECM composition and was important for the superior microhardness and fluoride release, suggesting its potential for higher stress-bearing site restorations. (AU)

• FAPESP's process: 16/13786-0 - Effect of Novel Nanotechnology to Conventional Glass Ionomer Cement on its Physical-Chemical-Biological Properties
• Grantee: Kamila Rosamilia Kantovitz
• Support Opportunities: Regular Research Grants