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Rearranged Terpenoids from the Marine Sponge Darwinella cf. oxeata and Its Predator, the Nudibranch Felimida grahami

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Author(s):
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Ramirez, Maria Camila A. ; Williams, David E. ; Gubiani, Juliana R. ; Parra, Lizbeth L. L. ; Santos, Mario F. C. ; Ferreira, Daiane D. ; Mesquita, Juliana T. ; Tempone, Andre G. ; Ferreira, Antonio G. ; Padula, Vinicius ; Hajdu, Eduardo ; Andersen, Raymond J. ; Berlinck, Roberto G. S.
Total Authors: 13
Document type: Journal article
Source: Journal of Natural Products; v. 80, n. 3, p. 6-pg., 2017-03-01.
Abstract

Marine sponges are a rich source of terpenoids with rearranged spongian carbon skeletons. Investigation of extracts from the sponge Darwinella cf. oxeata yielded four new rearranged diterpenoids, oxeatine (2) and oxeatamides H-J (35), as well as the known metabolites oxeatamide A (6), oxeatamide A methyl ester (7), and membranolide (1). Oxeatine (2) has a new heterocyclic skeleton, while oxeatamide J (5) has an N-methyl urea group included in a gamma-lactam moiety. UPLC-QTOF analysis of the extract obtained from the mantle of the nudibranch Felimida grahami indicated the presence of 1 and 4. (AU)

FAPESP's process: 15/01017-0 - Multi-use instrument approved and awarded in the project 2013/50228-8, name of instrument: ultra-performance liquid chromatograph coupled with a high resolution mass spectrometer
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: Multi-user Equipment Program
FAPESP's process: 13/50228-8 - Biodiversity components, and their metabolic characters, of Brazilian Islands: an integrated approach
Grantee:Roberto Gomes de Souza Berlinck
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants