| Author(s): |
Munhoz Jr, Antonio Hortencio
;
Romero Filho, Marcos
;
Kleist, Henrique de Arruda
;
Moreno, Guilherme Dias
;
de Oliveira, Mariana Oliva
;
Peres, Renato Meneghetti
;
Rossi, Maura Vincenza
;
de Miranda, Leila Figueiredo
;
Ribeiro, Roberto Rodrigues
;
Cardoso Sarmento, Bruno Filipe Carmelino
Total Authors: 10
|
| Document type: | Journal article |
| Source: | MATERIALS TODAY-PROCEEDINGS; v. 14, p. 8-pg., 2019-01-01. |
| Abstract | |
Pseudoboehmite is a hydrated aluminium compound produced by sol-gel process and used in drug delivery systems. The graphene oxide is a material that allows for many possibilities application as modify agent in a ceramic structure. The global prevalence and incidence of herpes simplex virus infections (HSV-1 and HSV-2) have risen worldwide. A big problem is that most persons with genital HSV infection have not received a diagnosis. Other concerning situation is that the herpes infected patients are more susceptible to HIV infections. It is also observed that in women the HSV infection are more common than in men. Acyclovir is an efficient drug for the treatment of herpes viruses. However, the oral bioavailability of acyclovir is limited due to varying and incomplete absorption. In this work, pseudoboehmite was produced with incorporation of graphene oxide in the gel. The pseudoboehmite-graphene oxide was used in in vitro drug delivery system for acyclovir. (C) 2019 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 17/22396-4 - "SYNTHESIS OF PSEUDOBOEHMITE NANOPARTICLES" |
| Grantee: | Antonio Hortencio Munhoz Junior |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 10/19157-9 - Synthesis of modified pseudoboehmite for use in drug delivery systems |
| Grantee: | Antonio Hortencio Munhoz Junior |
| Support Opportunities: | Regular Research Grants |