"SYNTHESIS OF PSEUDOBOEHMITE NANOPARTICLES"

• Grant number: 17/22396-4
• Support Opportunities: Regular Research Grants
• Start date: August 01, 2018
• End date: July 31, 2021
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Antonio Hortencio Munhoz Junior
• Grantee: Antonio Hortencio Munhoz Junior
• Host Institution: Escola de Engenharia (EE). Universidade Presbiteriana Mackenzie (UPM). Instituto Presbiteriano Mackenzie. São Paulo , SP, Brazil
• Associated researchers: Bruno Filipe Carmelino Cardoso Sarmento

Abstract

Pseudoboehmite is an aluminum compound with a structure similar to that of Boehmite. The unit cell of the pseudoboehmite is slightly larger than that of the boehmite because of a greater incorporation of water in the structure of the same. It has particles of nanometric dimensions and can be synthesized with extremely high purity. Several papers published in the literature show the potential of the use of this material in the controlled release of drugs including the treatment of cancer. The use of drugs in the form of complexes incorporated into polymer matrices and ceramic gels can lead to adequate control in gastrointestinal absorption when administered orally. As a consequence, there is the possibility of promoting a gradual action through progressive release of the drug, thus increasing its efficiency, reducing dose and toxicity. Previous studies have shown that pseudoboehmite is non-toxic and can be used for drug delivery. During the tests to determine the toxicity of this material, it was observed that in mice that took pseudoboehmite by gavage the blood glucose content was reduced. Since pseudoboehmite is obtained via low cost inorganic polymerization, molecules with different physicochemical characteristics can be incorporated into this high purity medium and the formed structure will be evaluated as a drug delivery system. In order to establish a profile of the influence of the physico-chemical properties of a molecule in the process of interaction with pseudoboehmite, a drug with recognized pharmacological activity, simvastatin (iupac name (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate). It is also sought to emphasize the importance of pseudoboehmite as a drug carrier, also serving as precursor of new therapeutic systems. The synthesis of pseudoboehmite from sodium hydroxide and aluminum chloride will be optimized with the aim of optimizing the release of simvastatin in in vitro and in vivo assays using Wistar rats. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MATHEUS FRANCELINO BEZERRA DA SILVA; CAROLINE VALADÃO PACHECO; RENATO MENEGHETTI PERES; LEILA FIGUEIREDO DE MIRANDA; NELSON BATISTA DE LIMA; RENE RAMOS DE OLIVEIRA; AYRTON BERNUSSI; ANTÔNIO HORTENCIO MUNHOZ JUNIOR. Synthesis of pseudoboehmite – effect of acetate ion. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 23, n. 1, 2020-03-13. (17/22396-4, 10/19157-9)

PACHECO, CAROLINE VALADAO; PERES, RENATO MENEGHETTI; CARRIERI, GABRIELA; MINUSSI, GIULIA REIS; ZAMBRANA, GUIDO PRANDINI; KANG, JESSICA SEONG HYUN; DE OLIVEIRA, RENE RAMOS; DE LIMA, NELSON BATISTA; BERNUSSI, AYRTON; WARZYWODA, JULIUSZ; et al. Cement-Based Composites Incorporating Pseudoboehmite Nanomaterials. JOURNAL OF MATERIALS IN CIVIL ENGINEERING, v. 35, n. 2, p. 11-pg., 2023-02-01. (10/19157-9, 17/22396-4)

PERES, RENATO MENEGHETTI; LEME SOUSA, JESSICA MAIARA; DE OLIVEIRA, MARIANA OLIVA; ROSSI, MAURA VINCENZA; DE OLIVEIRA, RENE RAMOS; DE LIMA, NELSON BATISTA; BERNUSSI, AYRTON; WARZYWODA, JULIUSZ; SARMENTO, BRUNO; MUNHOZ JR, ANTONIO HORTENCIO. Pseudoboehmite as a drug delivery system for acyclovir. SCIENTIFIC REPORTS, v. 11, n. 1, JUL 29 2021. (17/22396-4, 10/19157-9)

MUNHOZ JUNIOR, ANTONIO HORTENCIO; GALHARDO, GUSTAVO FIGUEIREDO; ORTEGA, FERNANDO DOS SANTOS; DE LIMA, NELSON BATISTA; MORAES, DENISON ANGELOTTI; DE MIRANDA, LEILA FIGUEIREDO; VALENZUELA-DIAZ, FRANCISCO ROLANDO; LI, B; LI, J; IKHMAYIES, S; et al. Alpha-Alumina Synthesis Using Gamma-Alumina Powders. CHARACTERIZATION OF MINERALS, METALS, AND MATERIALS 2019, v. N/A, p. 11-pg., 2019-01-01. (10/19157-9, 17/22396-4)

MUNHOZ JUNIOR, ANTONIO HORTENCIO; PACHECO, CAROLINE VALADAO; MELO, HENRIQUE TADEU T. S.; PERES, RENATO MENEGHETTI; DE ANDRADE E SILVA, LEONARDO GONDIM; LI, B; LI, J; IKHMAYIES, S; ZHANG, M; KALAY, YE; et al. Characterization of a Composite of High-Impact Polystyrene, Pseudoboehmite and Graphene Oxide. CHARACTERIZATION OF MINERALS, METALS, AND MATERIALS 2019, v. N/A, p. 12-pg., 2019-01-01. (17/22396-4, 10/19157-9)

MUNHOZ JR, ANTONIO HORTENCIO; ROMERO FILHO, MARCOS; KLEIST, HENRIQUE DE ARRUDA; MORENO, GUILHERME DIAS; DE OLIVEIRA, MARIANA OLIVA; PERES, RENATO MENEGHETTI; ROSSI, MAURA VINCENZA; DE MIRANDA, LEILA FIGUEIREDO; RIBEIRO, ROBERTO RODRIGUES; CARDOSO SARMENTO, BRUNO FILIPE CARMELINO. Synthesis of pseudoboehmite-graphene oxide for drug delivery system. MATERIALS TODAY-PROCEEDINGS, v. 14, p. 8-pg., 2019-01-01. (17/22396-4, 10/19157-9)

BEZERRA DA SILVA, MATHEUS FRANCELINO; PACHECO, CAROLINE VALADAO; PERES, RENATO MENEGHETTI; DE MIRANDA, LEILA FIGUEIREDO; DE LIMA, NELSON BATISTA; DE OLIVEIRA, RENE RAMOS; BERNUSSI, AYRTON; MUNHOZ JUNIOR, ANTONIO HORTENCIO. Synthesis of pseudoboehmite - effect of acetate ion. MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS, v. 23, n. 1, 2020. (17/22396-4, 10/19157-9)