| Full text | |
| Author(s): |
de Amorim, Marcelo R.
;
Hilario, Felipe
;
dos Santos Junior, Fernando M.
;
Batista Junior, Joaom.
;
Bauab, Tais M.
;
Araujo, Angela R.
;
Carlos, Iracilda Z.
;
Vilegas, Wagner
;
dos Santos, Lourdes C.
Total Authors: 9
|
| Document type: | Journal article |
| Source: | Planta Medica; v. 85, n. 11/12, p. 8-pg., 2019-08-01. |
| Abstract | |
Three new benzaldehyde derivatives, sporulosaldeins A - C ( 1 - 3 ), and 3 new benzopyran derivatives, sporulosaldeins D - F ( 4 - 6 ), were discovered from an endophytic fungus, Paraphaeosphaeria sp. F03, which was isolated from Paepalanthus planifolius leaves. Compounds 1 - 6 were elucidated by 1- and 2-dimensional nuclear magnetic resonance experiments and high-resolution mass spectrometry analysis. The absolute configuration of compound 5 was determined through the comparison of experimental and calculated electronic circular dichroism data. Compounds 1 - 6 were found to exhibit antifungal activity with minimum inhibitory concentration (MIC) values of 7.8 - 250 mu g/mL and racemic mixture of compound 6 exhibited weak cytotoxicity against MCF-7 and LM3 with IC (50) values of 34.4 and 39.2 mu M, respectively. (AU) | |
| FAPESP's process: | 15/11058-5 - Chemical and biological prospecting of endophytic fungi associated with Paepalanthus planifolius (Eriocaulaceae) |
| Grantee: | Marcelo Rodrigues de Amorim |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/25222-9 - Vibrational chiroptical spectroscopy for stereochemical characterization of small molecules and macromolecules |
| Grantee: | João Marcos Batista Junior |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 16/23794-0 - Stereochemistry of complex natural compounds by vibrational optical activity: acetogenins |
| Grantee: | Fernando Martins dos Santos Junior |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 15/04899-3 - Chemical study of the extracts produced by endophytic fungi associated with the aerial parts of Eriocaulaceae species and its antimicrobial activity |
| Grantee: | Lourdes Campaner dos Santos |
| Support Opportunities: | Regular Research Grants |