| Full text | |
| Author(s): Show less - |
Neves-Silva, Rodrigo
;
Almeida, Luciana Y.
;
Silveira, Heitor A.
;
Colturato, Carla B. N.
;
Duarte, Andressa
;
Ferrisse, Tulio M.
;
Silva, Evanio, V
;
Vanzolin, Barbara F.
;
Bufalino, Andreia
;
Ribeiro-Silva, Alfredo
;
Leon, Jorge E.
Total Authors: 11
|
| Document type: | Journal article |
| Source: | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. 42, n. 3, p. 11-pg., 2019-11-15. |
| Abstract | |
Background SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas are aggressive neoplasms, often affecting the sinonasal region. Not uncommonly, their diagnoses are made retrospectively. Methods Through SMARCB1 (INI-1) and NUT immunomarkers, 643 head and neck carcinomas were assessed retrospectively. Moreover, SMARCB1 (INI-1)-deficient and NUT carcinomas were additionally evaluated by immunohistochemistry, as well as in situ hybridization analysis for HPV and EBV. Results Four SMARCB1 (INI-1)-deficient carcinomas (located in lower lip, soft palate, hypopharynx and vocal cord, this latter high-risk HPV positive) and three NUT carcinomas (all located in oropharynx) were detected, previously diagnosed as nonkeratinizing or moderately differentiated squamous cell carcinoma. All cases showed squamous differentiation. NUT carcinomas than SMARCB1 (INI-1)-deficient carcinomas showed low overall survival rate. Conclusion The current cases expand the clinicopathological spectrum of SMARCB1 (INI-1)-deficient carcinomas and NUT carcinomas. Notably, the diagnosis of these cases is easily reached through immunohistochemistry, with impact on their accurate classification, treatment, and prognosis. (AU) | |
| FAPESP's process: | 16/02713-2 - Effects of erlotinib and gefitinib therapy in combination with all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: in vitro, ex vivo and murine experimental model studies. |
| Grantee: | Luciana Yamamoto de Almeida |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 16/11419-0 - Clinicopathological correlation of the degree of differentiation, tetraspanin expression, viral agents and cell proliferation in a large sample of squamous cell carcinoma of the head and neck region. |
| Grantee: | Jorge Esquiche León |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 18/12734-2 - Comparative immunohistochemical characterization of dendritic cell subgroups and viral oncogenesis in oral and oropharyngeal squamous cell carcinoma |
| Grantee: | Heitor Albergoni da Silveira |
| Support Opportunities: | Scholarships in Brazil - Master |