| Full text | |
| Author(s): |
Gustavo Henrique Ferreira Gonçalinho
[1]
;
Geni Rodrigues Sampaio
[2]
;
Rosana Aparecida Manólio Soares-Freitas
[3]
;
Nágila Raquel Teixeira Damasceno
[4]
Total Authors: 4
|
| Affiliation: | [1] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
[2] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
[3] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
[4] Universidade de São Paulo. Faculdade de Saúde Pública. Departamento de Nutrição - Brasil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Arquivos Brasileiros de Cardiologia; v. 120, n. 11 2023-11-20. |
| Abstract | |
Abstract Background While Omega-3 and omega-6 polyunsaturated fatty acids (n-3 and n-6 PUFAs) have established effects on cardiovascular disease (CVD) risk factors, little is known about their impacts on LDL quality markers. Objective To assess the associations of n-3 and n-6 PUFA within red blood cells (RBC) with LDL particle size, small dense LDL-c (sdLDL-c), and electronegative LDL [LDL(-)] in adults with CVD risk factors. Methods Cross-sectional study involving 335 men and women aged 30 to 74 with at least one cardiovascular risk factor. Analyses were conducted on biochemical parameters, such as glucose, insulin, HbA1c, C-reactive protein (CRP), lipid profile, lipoprotein subfractions, electronegative LDL particle [LDL(-)] and its autoantibody, and RBC n-3 and n-6 PUFAs. Independent t-test/Mann-Whitney test, one-way ANOVA/Kruskal-Wallis test, and multiple linear regressions were applied. All tests were two-sided, and a p-value of less than 0.05 was considered statistically significant. Results The RBC n-6/n-3 ratio was associated with increased LDL(-) (β = 4.064; 95% CI = 1.381 – 6.748) and sdLDL-c (β = 1.905; 95% CI = 0.863 – 2.947) levels, and reduced LDL particle size (β = -1.032; 95% CI = -1.585 − -0.478). Separately, n-6 and n-3 PUFAs had opposing associations with those parameters, reinforcing the protective effects of n-3 and showing the potential negative effects of n-6 on LDL particle quality. Conclusion RBC n-6 PUFA was associated with increased cardiometabolic risk and atherogenicity of LDL particles, while n-3 PUFA was associated with better cardiometabolic parameters and LDL particle quality. (AU) | |
| FAPESP's process: | 11/12523-2 - Physical and chemical properties of LDL and HDL, cardiometabolic and oxidative markers can be modulate by consumption of ômega-3, ômega-6 e ômega-9 in adult subjects? |
| Grantee: | Nágila Raquel Teixeira Damasceno |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 16/24531-3 - Structural and biophysics properties of native and modified lipoproteins |
| Grantee: | Antonio Martins Figueiredo Neto |
| Support Opportunities: | Research Projects - Thematic Grants |