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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sleep study, respiratory mechanics, chemosensitive response and quality of life in morbidly obese patients undergoing bariatric surgery: a prospective, randomized, controlled trial

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Oliveira, Luis V. F. [1] ; Aguiar, Isabella C. [1] ; Hirata, Raquel P. [1] ; Faria Junior, Newton S. [1] ; Reis, Israel S. [2] ; Sampaio, Luciana M. M. [1] ; Oliveira, Claudia S. [1] ; Carvalho, Paulo T. C. [1] ; Leitao Filho, Fernando S. S. [3] ; Giannasi, Lilian C. [2] ; Pinto, Lia Azevedo [4] ; Malheiros, Carlos Alberto [5] ; Freitas, Jr., Wilson Rodrigues [5]
Total Authors: 13
Affiliation:
[1] Nove de Julho Univ, Masters & Doctoral Degree Program Rehabil Sci, Sao Paulo - Brazil
[2] Nove de Julho Univ, Sleep Lab, Sao Paulo - Brazil
[3] Univ Fortaleza, Sch Med, Fortaleza, Ceara - Brazil
[4] Santa Casa de Misericordia Hosp, Psychol Serv, Sao Paulo - Brazil
[5] Santa Casa de Misericordia Hosp, Dept Surg, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: BMC SURGERY; v. 11, OCT 17 2011.
Web of Science Citations: 6
Abstract

Background: Obesity is a major public health problem in both developed and developing countries alike and leads to a series of changes in respiratory physiology. There is a strong correlation between obesity and cardiopulmonary sleep disorders. Weight loss among such patients leads to a reduction in these alterations in respiratory physiology, but clinical treatment is not effective for a long period of time. Thus, bariatric surgery is a viable option. Methods/Design: The present study involves patients with morbid obesity (BMI of 40 kg/m(2) or 35 kg/m(2) to 39.9 kg/m(2) with comorbidities), candidates for bariatric surgery, screened at the Santa Casa de Misericordia Hospital in the city of Sao Paulo (Brazil). The inclusion criteria are grade III morbid obesity, an indication for bariatric surgery, agreement to participate in the study and a signed term of informed consent. The exclusion criteria are BMI above 55 kg/m(2), clinically significant or unstable mental health concerns, an unrealistic postoperative target weight and/or unrealistic expectations of surgical treatment. Bariatric surgery candidates who meet the inclusion criteria will be referred to Santa Casa de Misericordia Hospital and will be reviewed again 30, 90 and 360 days following surgery. Data collection will involve patient records, personal data collection, objective assessment of HR, BP, neck circumference, chest and abdomen, collection and analysis of clinical preoperative findings, polysomnography, pulmonary function test and a questionnaire on sleepiness. Discussion: This paper describes a randomised controlled trial of morbidly obese patients. Polysomnography, respiratory mechanics, chemosensitive response and quality of life will be assessed in patients undergoing or not undergoing bariatric surgery. (AU)