Nanoparticle-Based Nitric Oxide Donors: Exploring Their Antimicrobial and Anti-Biofilm Capabilities

Author(s)

Tortella Fuentes, Gonzalo ; Fincheira, Paola ; Rubilar, Olga ; Leiva, Sebastian ; Fernandez, Ivette ; Schoebitz, Mauricio ; Pelegrino, Milena T. ; Paganotti, Andre ; dos Reis, Roberta Albino ; Seabra, Amedea B.

• Document type: Journal article
• Source: ANTIBIOTICS-BASEL; v. 13, n. 11, p. 22-pg., 2024-11-01.

Abstract

Background: Nitric oxide (NO) is an antimicrobial and anti-biofilm agent with significant potential for combating biofilm-associated infections and antibiotic resistance. However, owing to its high reactivity due to the possession of a free radical and short half-life (1-5 s), the practical application of NO in clinical settings is challenging. Objectives: This review explores the development of NO-releasing nanoparticles that provide a controlled, targeted delivery system for NO, enhancing its antimicrobial efficacy while minimizing toxicity. The review discusses various NO donors, nanoparticle platforms, and how NO disrupts biofilm formation and eradicates pathogens. Additionally, we examine the highly encouraging and inspiring results of NO-releasing nanoparticles against multidrug-resistant strains and their applications in medical and environmental contexts. This review highlights the promising role of NO-based nanotechnologies in overcoming the challenges posed by increasing antibiotic resistance and biofilm-associated infections. Conclusions: Although NO donors and nanoparticle delivery systems show great potential for antimicrobial and anti-biofilm uses, addressing challenges related to controlled release, toxicity, biofilm penetration, resistance, and clinical application is crucial. (AU)

• FAPESP's process: 22/14645-2 - Nitric oxide releasing hydrogels and vascular prosthesis for cardiovascular applications
• Grantee: Marcelo Ganzarolli de Oliveira
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 23/16363-7 - Duo-gasotransmitters for biomedical applications: bioformulation of nanoparticles containing Aspirin-NOSH
• Grantee: Roberta Albino dos Reis
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 23/12466-6 - Production of nano agricultural additives through biotransformation and functionalization of coffee waste
• Grantee: André Paganotti
• Support Opportunities: Scholarships in Brazil - Support Program for Fixating Young Doctors