| Full text | |
| Author(s): Show less - |
Silva, Laura Barros
;
Cruz, allefe Barbosa
;
Pereira, Douglas Henrique
;
Cassani, Natasha Marques
;
Ruiz, Uriel Enrique Aquino
;
Santos, Igor Andrade
;
Martins, Daniel Oliveira Silva
;
Nakahata, Douglas Hideki
;
Simoni, Deborah de Alencar
;
Kanavos, Ioannis
;
Ronga, Luisa
;
Lobinski, Ryszard
;
dos Santos Pereira, Anna Karla
;
Gomes Jardim, Ana Carolina
;
de Paiva, Raphael Enoque Ferraz
;
Corbi, Pedro Paulo
Total Authors: 16
|
| Document type: | Journal article |
| Source: | CHEMISTRYSELECT; v. 9, n. 37, p. 11-pg., 2024-10-01. |
| Abstract | |
In this paper, we report the synthesis, structural characterization, and antiviral properties of palladium(II) complexes with amantadine (atd) and memantine (mtn). Elemental and mass spectrometric analyses indicated a 1:2 metal/ligand ratio. The single crystal data for Pd-mtn revealed that the complex adopts a square geometry with the two memantine ligands bonded to Pd(II) by the nitrogen atoms of the NH2 group, in a trans configuration. Computational studies supported a similar structure for Pd-atd. The complexes were stable in DMSO solution for 24 h. The antiviral properties of Pd-atd and Pd-mtn were evaluated against Zika (ZIKV) and Chikungunya (CHIKV) viruses in vitro at their highest noncytotoxic concentrations. The Pd-atd (at 2 mu M) and Pd-mtn (at 10 mu M) complexes were able to impair 76% and 96% of CHIKV replication, respectively, which points the coordination of amantadine and memantine to Pd(II) as a successful strategy to increase their anti-CHIKV properties. Conversely, the Pd(II) complexes did not significantly inhibit the replication of ZIKV, which confirms the selectivity towards CHIKV. Interaction of the compounds with N-acetyl-l-cysteine, a model disulfide-containing peptide, and plasmid DNA pointed to Cys-containing peptides as more likely targets than nucleotides for the complexes. (AU) | |
| FAPESP's process: | 21/10265-8 - Cancer Theranostics Innovation Center (CancerThera) |
| Grantee: | Carmino Antonio de Souza |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 22/08320-3 - Synthesis, characterization and antiviral activity studies of Pd(II) with aminoadamantanes complexes. |
| Grantee: | Laura Barros Silva |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 21/08717-8 - Synthesis of copper, silver and gold complexes involving nucleotide analogues in the search of new alternatives for the treatment of ovarian cancer |
| Grantee: | Pedro Paulo Corbi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 17/11485-6 - Computational and theoretical developments based on ab initio methods and the Density Functional Theory |
| Grantee: | Rogério Custodio |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/08293-7 - CCES - Center for Computational Engineering and Sciences |
| Grantee: | Munir Salomao Skaf |
| Support Opportunities: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 23/14245-7 - SYNTHESIS, CHARACTERIZATION AND ANTIVIRAL STUDIES OF NOVEL Pd(II) COMPLEXES WITH AMINOADAMANTANES |
| Grantee: | Laura Barros Silva |
| Support Opportunities: | Scholarships abroad - Research Internship - Scientific Initiation |