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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Postprandial proximal gastric acid pocket in patients after laparoscopic Nissen fundoplication

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Author(s):
Herbella, Fernando A. M. [1, 2] ; Vicentine, Fernando P. P. [1] ; Del Grande, Jose C. [1] ; Patti, Marco G. [3]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Paulo, Dept Surg, Escola Paulista Med, Sao Paulo - Brazil
[2] Hosp Sao Paulo, Div Esophagus & Stomach, BR-04037003 Sao Paulo - Brazil
[3] Univ Chicago, Dept Surg, Chicago, IL 60637 - USA
Total Affiliations: 3
Document type: Journal article
Source: SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES; v. 25, n. 10, p. 3198-3201, OCT 2011.
Web of Science Citations: 6
Abstract

Background An unbuffered postprandial proximal gastric acid pocket (PPGAP) has been noticed in normal individuals and patients with gastroesophageal reflux disease (GERD). The role of gastric anatomy in the physiology of the PPGAP remains unclear. It is also unclear whether change in the PPGAP may contribute to GERD control. This study aims to analyze the presence of PPGAP in patients submitted to Nissen fundoplication. Methods Fifteen patients who had a laparoscopic Nissen fundoplication (mean age = 61 years, 13 females, mean time from operation 1 year) were studied. All patients were free of foregut symptoms. Patients underwent high-resolution manometry to identify the location of the lower border of the lower esophageal sphincter (LBLES).Station pull-through pH monitoring was performed from 5 cm below the LBLES to the LBLES in increments of 1 cm in a fasting state and 10 min after a standardized fatty meal. ResultsFour patterns of gastric acidity were found: (1) acid was not detected in the studied area of the stomach in 8 (53%) patients; (2) constant acidity (stomach is not alkalinized after meal), i.e., a buffered layer was not found in 3 (20%) patients; (3) PPGAP was not detected, i.e., the whole stomach is alkalinized, in 1 (7%) patient; and (4) PPGAP was noted in 3 (20%) patients with extensions of 2, 2, and 5 cm. Conclusion PPGAP is present in a minority of patients after Nissen fundoplication. This finding may explain part of the GERD control and that the gastric fundus may play a role in the genesis of the PPGAP. (AU)

FAPESP's process: 07/07940-8 - Evaluation of the gastric acid pocket in patients submitted to Roux-en-Y gastric bypass
Grantee:Fernando Augusto Mardiros Herbella Fernandes
Support Opportunities: Regular Research Grants