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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enantiomeric resolution of (+/-)-licarin A by high-performance liquid-chromatography using a chiral stationary phase

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Author(s):
Pereira, Ana Carolina [1] ; Magalhaes, Lizandra G. [1] ; Januario, Ana Helena [1] ; Pauletti, Patricia M. [1] ; Cunha, Wilson Roberto [1] ; Bastos, Jairo Kenupp [2] ; Nanayakkara, Dhammika N. P. [3, 4] ; e Silva, Marcio Luis A. [1]
Total Authors: 8
Affiliation:
[1] Univ Franca, Nacleo Ciencias Exatas & Tecnol, Grp Pesquisas Prod Nat, BR-14404600 Franca, SP - Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Ciencias Farmaceut, BR-14040903 Ribeirao Preto, SP - Brazil
[3] Univ Mississippi, Pharmaceut Sci Res Inst, Natl Ctr Nat Prod Res, University, MS 38677 - USA
[4] Univ Mississippi, Dept Pharmacognosy, Sch Pharm, University, MS 38677 - USA
Total Affiliations: 4
Document type: Journal article
Source: Journal of Chromatography A; v. 1218, n. 39, p. 7051-7054, SEP 28 2011.
Web of Science Citations: 5
Abstract

(+/-)-Licarin A (1), a neolignan obtained by the oxidative coupling reaction of isoeugenol, had in this study its enantiomers resolved. A novel, quick and efficient enantiomeric resolution of 1 was directly performed by chiral high-performance liquid chromatography (HPLC-PDA) protocol (CHIRALPACK (R) AD column; 9:1 (v/v) n-hexane:2-propanol; 1.0 mL/min). This method provided a chromatogram profile with a well-resolved peak separation. After isolation of each enantiomer with ee >99.9%, they were analysed in a polarimeter. Compound 2, which showed a retention time (t(r)) of 12.13 min, was the (+)-enantiomer and compound 3 (t(r) =18.90 min) was the (-)-enantiomer. (C) 2011 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/05049-2 - Development of polymeric nanaparticles and biodegradable systems containing lignans and evaluation its Chagas disease and schistosomiasis activities in vitro and in vivo
Grantee:Márcio Luís Andrade e Silva
Support Opportunities: Regular Research Grants
FAPESP's process: 09/15207-4 - Evaluation of the effect of lignans and neolignans on Schistosoma mansoni: a proteomic study
Grantee:Lizandra Guidi Magalhães
Support Opportunities: Scholarships in Brazil - Post-Doctoral