Toothpaste containing TiF 4 and chitosan against erosive tooth wear in situ.

Author(s)

Francese, Monique Malta ; Urasaki, Bruna Arisa Nakayama ; de Barros, Mariana Carvalho ; Ferrari, Carolina Ruis ; Grizzo, Larissa Tercilia ; Magalhaes, Ana Carolina

• Document type: Journal article
• Source: Journal of Dentistry; v. 145, p. 8-pg., 2024-04-09.

Abstract

Objective: This study compared the protective effect of an experimental TiF 4 /Chitosan toothpaste with a commercial toothpaste on the prevention of erosive tooth wear (ETW) in situ. Methods: Fifteen subjects took part in this crossover and double-blind study, in which they wore a palatal appliance containing 4 bovine enamel and 4 dentin in 3 phases (5 days each). Half of the samples were subjected to erosive challenges (90 s in 0.1 % citric acid, pH 2.5, 4 times/day), and the other half to erosive plus abrasive challenges (15 s plus 45 s of contact, 2 times/day). The phases corresponded to the application of the different toothpastes: 1) TiF 4 (1400 ppm F - ) plus Chitosan, 2) Elmex (R), Erosion Protection (1400 ppm F - , Chitosan), and 3) Placebo (negative control). Tooth wear was measured using contact profilometry (mu m) and submitted to twoway RM ANOVA/Tukey test ( p < 0.05). Results: No significant differences were detected between the experimental and commercial toothpastes, regardless of the challenge on both tissues. Both significantly reduce ETW compared to negative control ( p < 0.0006). Tooth wear was increased by brushing only on eroded enamel ( p < 0.01), but not on dentin ( p = 0.6085). TiF 4 /Chitosan [erosion 2.98 +/- 1.12 <mu>m vs. erosion and abrasion 3.12 +/- 1.33 mu m] and Elmex (R) toothpastes [erosion 2.35 +/- 0.93 mu m vs. erosion and abrasion 2.98 +/- 1.0 mu m] minimized the impact of brushing compared to placebo on enamel [erosion 4.62 +/- 1.48 mu m vs. erosion and abrasion 5.15 +/- 1.50 mu m]. Conclusions: TiF 4 plus chitosan toothpastes showed to be effective in minimizing the ETW as the commercial toothpaste is in situ. Clinical Relevance: The experimental toothpaste has similar effect against ETW compared to the commercial toothpaste. Considering the increased ETW prevalence worldwide, this result supports clinical trials and a possible application of this experimental anti-erosive toothpaste in the future. (AU)

• FAPESP's process: 22/07715-4 - Effect of toothpaste containing TiF4 and Chitosan on the reduction of erosive tooth wear in situ and of the development of enamel caries under a microcosm biofilm model
• Grantee: Monique Malta Francese
• Support Opportunities: Scholarships in Brazil - Doctorate