Influence of structural organization on mucoadhesive properties of poloxamer-hyaluronic acid-based micelles and hydrogels: From molecular modelling to biointerfaces interactions

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Sepulveda, Anderson Ferreira ; da Silva, Jessica Bassi ; Bruschi, Marcos Luciano ; Franco, Margareth K. K. D. ; Yokaichiya, Fabiano ; Tofoli, Giovana Radomille ; Cereda, Cintia Maria Saia ; Rosso, Anabella Patricia ; Giacomelli, Fernando Carlos ; Scott, Ana Ligia ; de Araujo, Daniele Ribeiro

• Document type: Journal article
• Source: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS; v. 698, p. 13-pg., 2024-06-22.

Abstract

New pharmaceutical formulations have been proposed as strategies to improve transport and provide best conditions to control the drug release rate in specific biological environments, such as mucosa surfaces. Herein, formulations containing binary systems Poloxamer (PL) 407 15 % and PL 338 15 %, combined with hyaluronic acid, carrying the local anesthetic bupivacaine (BVC), were studied by molecular dynamics, while other structural parameters were determined by Dynamic Light Scattering for stablishing relationships with mucoadhesive properties and cytotoxicity evaluation. The binary system PL 407 15 %/PL 338 15 % exhibited a well -organized structural morphology, with more hydrated corona, and increased mucoadhesive properties over mucin layers. After hyaluronic acid (HA) incorporation, it was observed an increase on the force of detachment, possibly due to HA role as a linker among mucin layers independently of PL supramolecular structures. On the other hand, the addition of BVC or HA/BVC into the binary system decreased the force of detachment, as a response of augmented of compactness of these hydrogels caused by desolvation of PO core, showing the influence of all components and their chemical interactions into the structural organization and their biopharmaceutical performance relationships. (AU)

• FAPESP's process: 19/20303-4 - Thermosensitive organogels as strategies for the treatment of inflammatory processes: from supramolecular structure to pharmacological evaluation
• Grantee: Daniele Ribeiro de Araujo
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/14668-2 - Engineering polymersomes of selective permeability towards nanoreactors for biocatalysis
• Grantee: Anabella Patricia Rosso
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 14/14457-5 - Lipid-based nanocarriers (SLN/NLC and remote-loading liposomes) used to improve the upload and potency of local anesthetics
• Grantee: Eneida de Paula
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 23/13068-4 - Peptide-based electrochemical biosensors for use in testing for anti-SARs-CoV-2
• Grantee: Anderson Ferreira Sepulveda
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/12071-6 - Tailoring colloids through supramolecular interactions: from fundamentals to applications
• Grantee: Watson Loh
• Support Opportunities: Research Projects - Thematic Grants