Cellulose from bacteria as a delivery system for improved treatment of infectious diseases: A review of updates and prospects

Author(s)

Roque-Borda, Cesar Augusto ; Canales, Christian S. Carnero ; Primo, Laura Maria Duran Gleriani ; Colturato, Vitoria Maria Medalha ; Polinario, Giulia ; Di Filippo, Leonardo Delello ; Duarte, Jonatas L. ; Chorilli, Marlus ; Barud, Hernane da Silva ; Pavan, Fernando R.

• Document type: Journal article
• Source: International Journal of Biological Macromolecules; v. 277, p. 18-pg., 2024-08-20.

Abstract

Cellulose from bacteria is a high-purity biomaterial naturally produced by bacteria as part of their metabolic process. Although it inherently lacks antimicrobial activity, its modification with bioactive substances can significantly enhance its efficacy beyond that of the original compounds. This biomaterial features a unique ability to retain substantial quantities of liquids within its three-dimensional network, making it a prime candidate for biomedical applications. Versatile in its properties, it can be utilized across various industries. Previous research has highlighted its capacity to exhibit antimicrobial properties and to encapsulate nano- structured materials, thereby augmenting its antibacterial effectiveness. This review focuses on the use of cellulose from bacteria as a carrier for active compounds, specifically targeting antibacterial activity against drug- resistant strains. We explore its role in innovative bacterial cellulose-based systems, which present a promising solution for tackling bacterial resistance. This review aims to showcase the potential of bacterial cellulose in developing new devices and treatment strategies that address critical concerns in global health. (AU)

• FAPESP's process: 23/01664-1 - Synthesis and characterization of antimicrobial peptide "B1CTcu5" analogs encapsulated in colon-specific microparticles and in vitro an in vivo studies against Mycobacterium tuberculosis
• Grantee: Fernando Rogério Pavan
• Support Opportunities: Regular Research Grants
• FAPESP's process: 21/14603-5 - Drug discovery and design: antimicrobial peptide B1CTcu5 analogs promising against Mycobacterium tuberculosis
• Grantee: Cesar Augusto Roque Borda
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• FAPESP's process: 20/16573-3 - In vitro and in vivo studies of antimicrobial peptide B1CTcu5 analogs encapsulated in colon-specific microparticles against Mycobacterium tuberculosis
• Grantee: Cesar Augusto Roque Borda
• Support Opportunities: Scholarships in Brazil - Doctorate