Advanced search
Start date
Betweenand


Evaluating the Cytotoxicity of Functionalized MWCNT and Microbial Biofilm Formation on PHBV Composites

Full text
Author(s):
Montanheiro, Thais Larissa do Amaral ; Schatkoski, Vanessa Modelski ; Camarena, Denisse Esther Mallaupoma ; de Oliveira, Thais Cardoso ; da Silva, Diego Morais ; Vegian, Mariana Raquel da Cruz ; Catalani, Luiz Henrique ; Koga-Ito, Cristiane Yumi ; Thim, Gilmar Patrocinio
Total Authors: 9
Document type: Journal article
Source: C-JOURNAL OF CARBON RESEARCH; v. 10, n. 2, p. 14-pg., 2024-06-01.
Abstract

This study focuses on the cytotoxic evaluation of functionalized multi-walled carbon nanotubes (MWCNT) and microbial biofilm formation on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanocomposites incorporating MWCNTs functionalized with gamma-aminobutyric acid (GABA) and carboxyl groups. The materials were characterized for cytotoxicity to fibroblasts and antimicrobial effects against Escherichia coli, Staphylococcus aureus and Candida albicans. The functionalization of MWCNTs was performed through oxidation (CNT-Ox) and GABA attachment (CNT-GB). The PHBV/CNT nanocomposites were produced via melt mixing. All MWCNT suspensions showed non-toxic behaviors after 24 h of incubation (viability higher than 70%); however, prolonged incubation and higher concentrations led to increased cytotoxicity. The antibacterial potential of PHBV/CNT nanocomposites against S. aureus showed a reduction in biofilm formation of 64% for PHBV/CNT-GB and 20% for PHBV/CNT-Ox, compared to neat PHBV. Against C. albicans, no reduction was observed. The results indicate promising applications for PHBV/CNT nanocomposites in managing bacterial infections, with GABA-functionalized CNTs showing enhanced performance. (AU)

FAPESP's process: 11/21442-6 - Synthetic and natural polymers applied to tissue engineering
Grantee:Luiz Henrique Catalani
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 17/24873-4 - PHBV and hydroxybutyrate functionalized CNT nanocomposite: kinetic study of crystallization and correlation with mechanical properties
Grantee:Thaís Larissa do Amaral Montanheiro
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 19/05856-7 - Use of low temperature atmospheric pressure plasma in dentistry: from laboratory bench to clinics
Grantee:Cristiane Yumi Koga Ito
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 20/12507-6 - Development and characterization of wollastonite cement for bone tissue engineering
Grantee:Gilmar Patrocínio Thim
Support Opportunities: Regular Research Grants
FAPESP's process: 18/13492-2 - Synthetic and natural scaffolds applied to regenerative medicine
Grantee:Luiz Henrique Catalani
Support Opportunities: Research Projects - Thematic Grants