A Review on Ultrasound-based Methods to Image the Distribution of Magnetic Nanoparticles in Biomedical Applications

Author(s)

Huber, Christian Marinus ; Pavan, Theo Z. ; Ullmann, Ingrid ; Heim, Christian ; Rupitsch, Stefan J. ; Vossiek, Martin ; Alexiou, Christoph ; Ermert, Helmut ; Lyer, Stefan

• Document type: Journal article
• Source: ULTRASOUND IN MEDICINE AND BIOLOGY; v. 51, n. 2, p. 25-pg., 2024-12-19.

Abstract

Magnetic nanoparticles (MNPs) have gained significant attention in biomedical engineering and imaging applications due to their unique magnetic and mechanical properties. With their high magnetization and small size, MNPs serve as excitation sources for magnetically heating to destroy tumors (magnetic hyperthermia) and magnetically controlled drug carriers in magnetic drug targeting. However, effectively visualizing the distribution of MNPs during research or potential clinical use with low-cost modalities remains a critical challenge. Although magnetic resonance imaging provides pre- and post-procedural imaging, it is considered to be high cost, and realtime imaging during clinical procedures is limited. In contrast, ultrasound-based imaging methods offer the advantage of providing the potential for immediate feedback during clinical use and are considered to be a lowcost modality. Ultrasound-based imaging techniques, including magnetomotive ultrasound, magnetoacoustic tomography, and thermoacoustic imaging, emerged as promising approaches for imaging the distribution of MNPs. These techniques offer the potential for real-time imaging, facilitating precise therapy monitoring. By exploring the strengths and limitations of various ultrasound-based imaging techniques for MNPs, this review seeks to provide comprehensive insights that can guide researchers in selecting suitable ultrasound-based modalities and inspire further advancements in this exciting field. (AU)

• FAPESP's process: 21/06728-2 - Photoacoustic and ultrasound imaging for theranostic purposes
• Grantee: Theo Zeferino Pavan
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 18/16939-8 - Development and implementation of novel acoustic, magnetic and optical techniques for diagnostic and therapeutic applications
• Grantee: Antonio Adilton Oliveira Carneiro
• Support Opportunities: Research Projects - Thematic Grants