Label-free ADAM10 capacitive assay for the early diagnosis of Alzheimer's disease

Author(s)

Garrote, Beatriz L. ; Lopes, Lais C. ; Cominetti, Marcia R. ; Faria, Ronaldo C. ; Bueno, Paulo R.

• Document type: Journal article
• Source: SENSORS AND ACTUATORS B-CHEMICAL; v. 427, p. 8-pg., 2025-03-15.

Abstract

This study demonstrates a quantum capacitance-based approach using a peptide-redox-active interface modified with Ab1 and Ab2 ADAM10 isoform antibodies for the development of label-free and point-of-care assays that enable high-accuracy quantification of the target analyte in plasma samples. The sensitivity of the quantum capacitance to changes in interface energy upon analyte binding suggests significant potential for creating miniaturized diagnostic devices for non-communicable diseases, including Alzheimer's disease. (AU)

• FAPESP's process: 17/24839-0 - Nanoelectronics and nanoscale electrochemistry: fundaments and applications
• Grantee: Paulo Roberto Bueno
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 18/26273-7 - Label-free electrochemical capacitive biosensors for disease diagnosis
• Grantee: Beatriz Lucas Garrote
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/01863-9 - Biology and function of ADAM10 isoforms for differential diagnosis of Alzheimer's Disease by electrochemical sensors
• Grantee: Márcia Regina Cominetti
• Support Opportunities: Research Projects - Thematic Grants