| Full text | |
| Author(s): |
Daniele Scherer
[1]
;
Beatriz Figueiredo Leite
[2]
;
Melissa Aparecida Morimoto
[3]
;
Thauana Luiza Oliveira
[4]
;
Barbara N. Carvalho Klemz
[5]
;
Rosana A. M. Soares Freitas
[6]
;
Caroline Pappiani
[7]
;
Nágila R. Teixeira Damasceno
[8]
;
Marcelo de Medeiros Pinheiro
[9]
Total Authors: 9
|
| Affiliation: | [1] Federal University of São Paulo. Paulista School of Medicine. Rheumatology Division - Brasil
[2] Federal University of São Paulo. Paulista School of Medicine. Rheumatology Division - Brasil
[3] Federal University of São Paulo. Paulista School of Medicine. Rheumatology Division - Brasil
[4] Federal University of São Paulo. Paulista School of Medicine. Rheumatology Division - Brasil
[5] Federal University of São Paulo. Paulista School of Medicine. Rheumatology Division - Brasil
[6] University of São Paulo. School of Public Health. Nutrition Department - Brasil
[7] University of São Paulo. School of Public Health. Nutrition Department - Brasil
[8] University of São Paulo. School of Public Health. Nutrition Department - Brasil
[9] Federal University of São Paulo. Paulista School of Medicine. Rheumatology Division - Brasil
Total Affiliations: 9
|
| Document type: | Journal article |
| Source: | ADVANCES IN RHEUMATOLOGY; v. 64, 2024-08-19. |
| Abstract | |
Abstract Introduction Patients with psoriatic arthritis have some lipid metabolism changes and higher risk of metabolic syndrome (MetS) and cardiovascular diseases, regardless of traditional risk factors, suggesting that chronic inflammation itself plays a central role concerning the atherosclerosis. However, there is a lack of information regarding atherogenic pattern and lipoprotein subfractions burden in these individuals. Aim To evaluate the HDL and LDL-cholesterol plasmatic levels and their subfractions after a nutritional intervention in patients with psoriatic arthritis (PsA). Methods This was a randomized, placebo-controlled clinical trial of a 12-week nutritional intervention. PsA patients were randomly assigned to 1-Placebo: 1 g of soybean oil daily, no dietetic intervention; 2-Diet + Supplementation: an individualized diet, supplemented with 604 mg of omega-3 fatty acids, three times a day; and 3-Diet + Placebo: individualized diet + 1 g of soybean oil. The LDL subfractions were classified as non-atherogenic (NAth), atherogenic (Ath) or highly atherogenic (HAth), whereas the HDL subfractions were classified as small, medium, or large particles, according to the current recommendation based on lipoproteins electrophoresis. Results A total of 91 patients were included in the study. About 62% of patients (n = 56) had an Ath or HAth profile and the main risk factors associated were male gender, longer skin disease duration and higher BMI. Thirty-two patients (35%) had a high-risk lipoprotein profile despite having LDL plasmatic levels below 100 mg/dL. The 12-week nutritional intervention did not alter the LDL subfractions. However, there were significant improvement of HDL subfractions. Conclusion Recognizing the pro-atherogenic subfractions LDL pattern could be a relevant strategy for identifying PsA patients with higher cardiovascular risk, regardless total LDL plasmatic levels and disease activity. In addition, a short-term nutritional intervention based on supervised and individualized diet added to omega-3 fatty acids changed positively the HDLLARGE subfractions, while LDLLARGE subfraction was improved in hypercholesterolemic individuals. ClinicalTrials.gov identifier: NCT03142503 (http://www.clinicaltrials.gov/). (AU) | |
| FAPESP's process: | 12/18701-2 - Effectiveness of a dietary intervention program on the disease activity, metabolic profile and oxidative stress in patients with psoriatic arthritis and psoriasis activity: a clinical, randomized, placebo-controlled study |
| Grantee: | Marcelo de Medeiros Pinheiro |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/18789-7 - Association between dietary intake, metabolic profile and oxidative stress in psoriasis and psoriatic arthritis patients |
| Grantee: | Beatriz Figueiredo Leite |
| Support Opportunities: | Scholarships in Brazil - Master |