Serum Proteomics of Experimental Malaria-Associated ARDS Reveals a Regulation of Acute-Phase Response Proteins

Author(s)

Rosa-Fernandes, Livia ; Santiago, Veronica Feijoli ; Silva-Santos, Yasmin da ; Lopes, Tissiane Tarosso ; Peixoto, Erika Paula Machado ; Rodrigues, Stefani Aparecida Minchio ; Marinho, Claudio Romero Farias ; Palmisano, Giuseppe ; Epiphanio, Sabrina

• Document type: Journal article
• Source: JOURNAL OF IMMUNOLOGY RESEARCH; v. 2025, n. 1, p. 13-pg., 2025-01-01.

Abstract

Malaria is a parasitic infectious disease considered a public health problem. Acute respiratory distress syndrome (ARDS) is a complication in malaria-infected individuals with a high mortality rate (80% to 100%) and can occur before, during, or after antimalarial drug treatment. Although inflammation and epithelial/endothelial injury pathways have been determined through these studies, specific circulating malaria-associated ARDS markers have not yet been established. We applied a quantitative mass spectrometry (MS)-based proteomic approach to identify altered molecular pathways in a mouse model of malaria-associated ARDS. Acute-phase response (APR) proteins were regulated in the ARDS group, suggesting their potential involvement in the development of the syndrome. They may serve as biomarkers when analyzed alongside other proteins that require further investigation. Additionally, the regulation of APR proteins in the ARDS group provides valuable insights into the pathophysiology of ARDS, contributing to a better understanding of the syndrome. (AU)

• FAPESP's process: 20/03163-1 - Pulmonary proteomic profile of Malaria-associated Acute Respiratory Distress Syndrome: identification and validation of biomarkers
• Grantee: Sabrina Epiphanio
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/15549-1 - Post-translational modifications in Chagas Disease biological processes and diagnostics: novel methodological approaches and biological applications
• Grantee: Giuseppe Palmisano
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 22/08582-8 - The role of septin 9 in the regulation of vascular permeability in malaria-associated acute respiratory distress syndrome
• Grantee: Stefani Aparecida Minchio Rodrigues
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 20/04923-0 - SARS-CoV-2 glycosylation: a blueprint structural insight for understanding COVID-19 pathogenesis
• Grantee: Giuseppe Palmisano
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/06747-4 - Study of the humoral immune response in recurrent infections by Plasmodium vivax in pregnant women from Amazon region
• Grantee: Cláudio Romero Farias Marinho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 23/05478-8 - The regulation of Septin 9 in Malaria-associated Acute Respiratory Distress Syndrome: from cytoadhesion to increased vascular permeability
• Grantee: Sabrina Epiphanio
• Support Opportunities: Regular Research Grants
• FAPESP's process: 22/13150-0 - Malaria-induced inflammation: a novel pathway for cardiovascular disease
• Grantee: Cláudio Romero Farias Marinho
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/20468-0 - Recrudescence of the malaria during pregnancy: effects and mechanisms
• Grantee: Cláudio Romero Farias Marinho
• Support Opportunities: Regular Research Grants