| Full text | |
| Author(s): |
Kunioka, Carlos Tadashi
;
Souza, Vanessa Cristina de Oliveira
;
Rocha, Bruno Alves
;
Barbosa Junior, Fernando
;
Belo, Luis
;
Manso, Maria Conceicao
;
Carvalho, Marcia
Total Authors: 7
|
| Document type: | Journal article |
| Source: | TOXICS; v. 13, n. 6, p. 16-pg., 2025-06-10. |
| Abstract | |
Osteoporosis is a major public health concern, particularly among postmenopausal women. Environmental exposure to metals has been proposed as a potential contributor to osteoporosis, but human data remain limited and inconsistent. This study investigated changes in urinary concentrations of 20 metal(loid)s in patients with osteoporosis, as well as the association of these elements with bone mineral density (BMD), in a cohort of 380 postmenopausal women aged 50-70 years from Cascavel, Paran & aacute;, Brazil. Demographic, lifestyle, and clinical data were collected, and urinary concentrations of aluminum (Al), barium (Ba), cadmium (Cd), cobalt (Co), cesium (Cs), copper (Cu), mercury (Hg), lithium (Li), manganese (Mn), molybdenum (Mo), nickel (Ni), lead (Pb), rubidium (Rb), antimony (Sb), selenium (Se), tin (Sn), strontium (Sr), thallium (Tl), uranium (U), and zinc (Zn) were measured by inductively coupled plasma mass spectrometry. BMD was assessed at the lumbar spine, femoral neck, and total hip using dual-energy X-ray absorptiometry. Osteoporosis was diagnosed in 73 participants (19.2%). Osteoporotic women had significantly higher urinary concentrations of Cd, Mn, Pb, Sb, Sn, and Zn (p < 0.05). Statistically significant negative correlations were observed between BMD and urinary concentrations of Al, Cd, Hg, Mn, Sb, and U. After adjustment for confounders, elevated urinary concentrations of Cd, Mn, Pb, and Sb remained independently and significantly associated with higher odds of osteoporosis, with Cd (aOR = 1.495; p = 0.026) and Sb (aOR = 2.059; p = 0.030) showing the strongest associations. In addition, women with urinary concentrations above the 90th percentile for both Cd and Sb had a significantly higher prevalence of osteoporosis compared to those with lower levels (44.4% vs. 18.0%; p = 0.011). Longitudinal studies are needed to confirm causality and inform prevention strategies. (AU) | |
| FAPESP's process: | 21/05059-0 - Multi-user equipment approved in grant 2018/24069-3: Inductively Coupled Plasma Mass Spectrometry (ICP-MS) |
| Grantee: | Fernando Barbosa Júnior |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 18/24069-3 - ReSEARCH: Recognizing Signatures of the Exposome to Anticipate the Risks for a Continuous Health |
| Grantee: | Fernando Barbosa Júnior |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 22/06443-0 - Bioavailability and bioaccessibility of pesticides and legacy pollutants in food: a public health risk assessment and creation of a risk-benefit tool for Brazilian consumers |
| Grantee: | Marília Cristina Oliveira Souza |
| Support Opportunities: | Generation Project Research Grant |
| FAPESP's process: | 23/12363-2 - Association between the co-exposure to endocrine disrupting chemicals and birth outcomes in Brazilian newborns: a cross-sectional study using elastic net and Bayesian kernel machine regression |
| Grantee: | Jonas Carneiro Cruz |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 23/03654-3 - Development and application of simple and rapid analytical methods for the determination of endocrine disruptors and oxidative stress biomarkers in biological samples for evaluation of exposure of children and pregnant women |
| Grantee: | Jonas Carneiro Cruz |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |