| Full text | |
| Author(s): |
Mosquim, Victor
;
Santin, Daniella Cristo
;
Jacomine, Juliana Carvalho
;
Zabeu, Giovanna Speranza
;
Gillam, David Geoffrey
;
Hill, Robert Graham
;
Wang, Linda
Total Authors: 7
|
| Document type: | Journal article |
| Source: | Journal of Dentistry; v. 160, p. 8-pg., 2025-09-01. |
| Abstract | |
Objectives To investigate whether a TiF4 varnish, a SnCl2/AmF/NaF and chitosan-containing toothpaste (Elmex Opti-namel), and a fluoride-calcium-phospho-silicate-containing toothpaste (Biomin F) can reduce dentin hypersensitivity (DH) and improve oral health-related quality of life (OHRQoL) similarly to NaF varnish over 6 months. Methods Fifty-one patients/241 teeth were randomized into four groups. DH was measured using a 10-point visual analog scale after evaporative and tactile stimuli at baseline, immediately after application, and after 1, 3, and 6 months. OHRQoL was evaluated using the OHIP-14 questionnaire at baseline and after 1, 3, and 6 months. Statistical analyses included one-way ANOVA, Fisher's exact test, Kruskal-Wallis and DSCF post-hoc, Friedman's test and Durbin-Conover post-hoc, and mixed factorial ANOVA with Tukey post-hoc (alpha=0.05). Results All products reduced DH pain over time (p < 0.001). For evaporative stimulus, NaF varnish was outperformed by both toothpastes at 3 months, and by Elmex Opti-namel at 6 months (p = 0.048). For tactile stimulus, Biomin F was less effective than NaF varnish immediately after application (p = 0.028), but no other inter-group differences were observed. All products equally improved OHRQoL (p < 0.001), but the improvement was classified as low. Conclusion All products improved OHRQoL, but Elmex Opti-namel provided the most effective pain relief after 6 months. Clinical Significance All products relieved pain and improved OHRQoL. However, both toothpastes presented higher DH pain relief than the NaF varnish after 3 months, and Elmex Opti-namel outperformed the NaF varnish after 6 months. Therefore, bioactive glass- and polyvalent metal-containing toothpastes are effective, noninvasive options for managing DH and enhancing patient comfort. (AU) | |
| FAPESP's process: | 19/21128-1 - The role of bioactive, resinous and fluoridated agents in the treatment of dentin hypersensitivity and their interaction with sound and eroded dentin: in vitro and clinical studies |
| Grantee: | Victor Mosquim |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 21/07513-0 - Dentinal tubules occlusion after application of experimental toothpastes containing bioactive glasses: a magical angle spinning-nuclear magnetic resonance (MAS-NMR) analysis |
| Grantee: | Victor Mosquim |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate |
| FAPESP's process: | 23/16722-7 - Development of self-etching adhesive systems combined with bioactive particles containing fluoride and strontium with or without sodium and zinc: analysis of adhesive properties and remineralization of the dentin matrix |
| Grantee: | Victor Mosquim |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 23/05793-0 - Impact of bioactive technologies on altered dentin by erosive tooth wear or post irradiated with radiotherapy: biological assessment by in situ zymography and related physical-mechanical properties |
| Grantee: | Linda Wang |
| Support Opportunities: | Regular Research Grants |