Chemical, spectroscopic characterization and antibacterial activities in vitro of a novel gold(I)-ibuprofen complex

Author(s)

Fiori, Ana Thereza M. ^[1] ; Lustri, Wilton R. ^[2] ; Magalhaes, Alvicler ^[1] ; Corbi, Pedro P. ^[1]

Affiliation

^[1] Univ Estadual Campinas, Inst Quim, UNICAMP, BR-13083970 Campinas, SP - Brazil

^[2] Assoc Sao Bento Ensino, Ctr Univ Araraquara, UNIARA, BR-14801320 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Inorganic Chemistry Communications; v. 14, n. 5, p. 738-740, MAY 2011.
• Web of Science Citations: 13

Abstract

A novel gold(I) complex with ibuprofen was synthesized and characterized by chemical and spectroscopic measurements. Elemental analysis led to the composition AuC(14)H(18)O(2)N. Infrared, (1)H and (13)C NMR data suggest coordination of the ligand to Au(I) through the oxygen atom of the carboxylic group in a monodentate form. An antibiotic sensitive profile indicated antibacterial activity in vitro of the complex against Gram-negative (E. coli and P. aeruginosa) and Gram-positive (S. aureus) microorganisms. (C) 2011 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 10/00667-7 - Synthesis, characterization and pharmacological applications of new metal complexes with the anti-inflammatory Ibuprofen
• Grantee: Ana Thereza Fiori Duarte
• Support Opportunities: Scholarships in Brazil - Scientific Initiation