Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor-alpha and negatively with adiponectin levels in obese adolescents

Author(s):Show less -

Lira, Fabio Santos ^[1] ; Rosa, Jose Cesar ^[1] ; dos Santos, Ronaldo Vagner ^[2] ; Venancio, Daniel Paulino ^[3] ; Carnier, June ^[1] ; Sanches, Priscila de Lima ^[1] ; Oller do Nascimento, Claudia Maria ^{[1, 4]} ; de Piano, Aline ^[1] ; Tock, Lian ^[1] ; Tufik, Sergio ^[3] ; de Mello, Marco Tulio ^{[3, 1]} ; Damaso, Ana R. ^{[1, 2]} ; Oyama, Lila Missae ^{[1, 2]}

Affiliation

^[1] Univ Fed Sao Paulo, Postgrad Program Nutr, BR-04020060 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Biosci, BR-04020060 Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Psychobiol, BR-04020060 Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Dept Physiol, BR-04020060 Sao Paulo - Brazil

• Document type: Journal article
• Source: METABOLISM-CLINICAL AND EXPERIMENTAL; v. 60, n. 3, p. 359-365, MAR 2011.
• Web of Science Citations: 34

Abstract

The purpose of this study was to assess the level of cytokine expression in correlation with visceral and subcutaneous fat in obese adolescents admitted to long-term interdisciplinary weight loss therapy. The study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (18, aged 15-19 years) with body mass indexes greater than the 95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. Visceral and subcutaneous fat was analyzed by ultrasonography. Blood samples were collected to analyze tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-10 (IL-10), and adiponectin concentrations that were measured by enzyme-linked immunosorbent assay. The most important finding in the present investigation is that the long-term interdisciplinary lifestyle therapy decreased visceral fat. Positive correlations between IL-6 levels and visceral fat (r = 0.42, P < .02) and TNF-alpha levels and visceral fat (r = 0.40, P < .05) were observed. Negative correlations between TNF-alpha levels and subcutaneous fat (r = -0.46, P < .01) and adiponectin levels and subcutaneous fat (r = -0.43, P < .03) were also observed. In addition, we found a positive correlation between TNF-alpha levels and the visceral to subcutaneous fat ratio (r = 0.42, P < .02) and a negative correlation between adiponectin level and the visceral to subcutaneous fat ratio (r = -0.69, P < .001). Despite the limitation of sample size, our results indicate that the observed massive weight loss (mainly visceral fat) was highly correlated with a decreased inflammatory state, suggesting that the interdisciplinary therapy was effective in decreasing inflammatory markers. (C) 2011 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 06/00684-3 - Orexigenic, anorexigenic, pro and pre-inflamatory factors: effects of a multidisciplinary program for weight reduction in obese adolescents
• Grantee: Ana Raimunda Dâmaso
• Support Opportunities: Regular Research Grants