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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial Activity of Terpenoids from Copaifera langsdorffii Desf. Against Cariogenic Bacteria

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Souza, Ariana B. [1] ; Martins, Carlos H. G. [1] ; Souza, Maria G. M. [1] ; Furtado, Niege A. J. C. [2] ; Heleno, Vladimir C. G. [1] ; de Sousa, Joao P. B. [2] ; Rocha, Erilda M. P. [1] ; Bastos, Jairo K. [2] ; Cunha, Wilson R. [1] ; Veneziani, Rodrigo C. S. [1] ; Ambrosio, Sergio R. [1]
Total Authors: 11
[1] Univ Franca, Nucleo Pesquisa Ciencias Exatas & Tecnol, Franca, SP - Brazil
[2] Univ Sao Paulo, Dept Ciencias Farmaceut, Fac Ciencias Farmaceut Ribeirao Preto, Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Phytotherapy Research; v. 25, n. 2, p. 215-220, FEB 2011.
Web of Science Citations: 62

In the present work, the anticariogenic activities of nine labdane type-diterpenes and four sesquiterpenes were investigated. Among these metabolites, (-)-copalic acid (CA) was the most active compound displaying MIC values very promising (ranging from 2.0 to 6.0 mu g/mL) against the main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, S. mutans, S. mitis, S. sanguinis and Lactobacillus casei. Time kill assays performed with CA against the primary causative agent (S. mutans) revealed that, in the first 12 h, this compound only inhibits the growth of the inoculum (bacteriostatic effect). However, its bactericidal effect is clearly noted thereafter (between 12 and 24 h). Also, CA did not show a synergistic effect when combined with the anticariogenic gold standard (chlorhexidine, CHD) in the checkerboard assays against S. mutans. In conclusion, the results points out CA as an important metabolite in the search for new effective anticariogenic agents. Copyright (C) 2010 John Wiley \& Sons, Ltd. (AU)

FAPESP's process: 07/54762-8 - Obtaining structural analogues of pimaradienoic acid through the process of fungal biotransformation and study of the effect of these metabolites on the activity of the TcDHODH enzyme and on the contraction of the vascular smooth muscle of the aorta artery of mice
Grantee:Sergio Ricardo Ambrosio
Support type: BIOTA-FAPESP Program - Young Investigators Grants
FAPESP's process: 08/09656-8 - Diterpenes obtained from the oleoresin of the Copaifera langsdorffii Desf.: isolation, chemical elucidation and antimicrobial activity
Grantee:Ariana Borges Souza
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 09/09438-3 - Copaifera langsdorfii oleoresin: isolation of secondary metabolites, evaluation of their antimicrobial potential against oral pathogens and development and validation of analytical methodology by HPLC.
Grantee:Rodrigo Cassio Sola Veneziani
Support type: Regular Research Grants