Depot-specific modulation of adipokine levels in rat adipose tissue by diet-induced obesity: The effect of aerobic training and energy restriction

Author(s):Show less -

Yamashita, Alex Shimura ^[1] ; Lira, Fabio Santos ^{[2, 1]} ; Rosa, Jose Cesar ^[2] ; Paulino, Ellena Christina ^[3] ; Brum, Patricia Chakur ^[4] ; Negrao, Carlos Eduardo ^{[4, 3]} ; dos Santos, Ronaldo Vagner ^[5] ; Batista, Jr., Miguel Luiz ^[1] ; do Nascimento, Claudia Oller ^[2] ; Oyama, Lila Missae ^[5] ; Seelaender, Marilia ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Physiol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Med, Inst Heart, Sao Paulo - Brazil

^[4] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Biosci, Sao Paulo - Brazil

• Document type: Journal article
• Source: CYTOKINE; v. 52, n. 3, p. 168-174, DEC 2010.
• Web of Science Citations: 30

Abstract

The present study examined the effects of aerobic training and energy restriction on adipokines levels in mesenteric (MEAT) and retroperitoneal (RPAT) white adipose tissue from obese rats. Male Wistar rats were fed with standard laboratory diet (Control group) or high fat diet (HFD). After 15 weeks, HFD rats were randomly assigned to the following groups: rats submitted to HFD, which were sedentary (sedentary HFD, n = 8) or trained (trained HFD, n = 8); or submitted to energy-restriction (ER), which were sedentary (sedentary ER, n = 8) or trained (trained ER, n = 8). Trained rats ran on a treadmill at 55% VO(2max) for 60 min/day, 5 days/week, for 10 weeks. ER rats were submitted to a reduction of 20% daily caloric ingestion compared to the Control group. ER and aerobic training decreased body weight, MEAT and RPAT absolute weight, and fat mass. IL-6, IL-10 and TNF-alpha levels were decreased and adiponectin did not change in RPAT in response to ER protocol. On the other hand, ER and the aerobic training protocol decreased IL-6, TNF-alpha and adiponectin levels in MEAT. Absolute MEAT weight showed a positive correlation with IL-6 (r = 0.464), INF-alpha (r = 0.508); and adiponectin (r = 0.342). These results suggest a tissue-specific heterogeneous response in adipokines level. The combination of the protocols (aerobic training and energy restriction) did not induce an enhanced effect. Published by Elsevier Ltd. (AU)

• FAPESP's process: 05/01445-0 - The role of PPARs in cancer cachexia
• Grantee: Marilia Cerqueira Leite Seelaender
• Support Opportunities: Regular Research Grants