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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Postprandial Proximal Gastric Acid Pocket in Patients after Roux-En-Y Gastric Bypass

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Author(s):
Herbella, Fernando A. M. [1, 2] ; Vicentine, Fernando P. P. [1] ; Del Grande, Jose C. [1] ; Patti, Marco G. [3] ; Arasaki, Carlos H. [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Dept Surg, Escola Paulista Med, Sao Paulo - Brazil
[2] Hosp Sao Paulo, Div Esophagus & Stomach, BR-04037003 Sao Paulo - Brazil
[3] Univ Chicago, Dept Surg, Chicago, IL 60637 - USA
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF GASTROINTESTINAL SURGERY; v. 14, n. 11, p. 1742-1745, NOV 2010.
Web of Science Citations: 11
Abstract

An unbuffered postprandial proximal gastric acid pocket (PPGAP) has been noticed in normal individuals and patients with gastroesophageal reflux disease (GERD). The role of gastric anatomy in the physiology of the PPGAP remains unclear. It is also unclear whether operations that control GERD, such as Roux-en-Y gastric bypass (RYGB) and Nissen fundoplication, change the PPGAP. This study aims to analyze the presence of PPGAP in patients submitted to RYGB. Fifteen patients who had a RYGB for morbid obesity (mean age 53 years, 14 females, mean time from operation 3 years) were studied. All patients were free of foregut symptoms. Patients underwent a high-resolution manometry to identify the location of the lower border of the lower esophageal sphincter (LBLES). A station pull-through pH monitoring was performed from 5 cm below the LBLES to the LBLES in increments of 1 cm in a fasting state and 10 min after a standardized fatty meal (40 g of chocolate, 50% fat). Acidity was not detected in the stomach of four patients before meal. After meal, PPGAP was not found in eight patients. In three patients, a PPGAP was noted with an extension of 1 to 3 cm. PPGAP is present in a minority of patients after RYGB; this finding may explain part of the GERD control after RYGB and that the gastric fundus may play a role in the genesis of the PPGAP. (AU)

FAPESP's process: 07/07940-8 - Evaluation of the gastric acid pocket in patients submitted to Roux-en-Y gastric bypass
Grantee:Fernando Augusto Mardiros Herbella Fernandes
Support Opportunities: Regular Research Grants